Peroxide bond-dependent antiplasmodial specificity of arternisinin and OZ277 (RBx11160)

被引：78

作者：

Kaiser, Marcel

Wittlin, Sergio

Nehrbass-Stuedli, Angela

Dong, Yuxiang

Wang, Xiaofang

Hemphill, Andrew

Matile, Hugues

Brun, Reto

Vennerstrom, Jonathan L.

机构：

[1] Univ Nebraska, Med Ctr, Coll Pharm, Omaha, NE 68198 USA

[2] Swiss Trop Inst, CH-4002 Basel, Switzerland

[3] Univ Bern, Inst Parasitol, CH-3012 Bern, Switzerland

[4] F Hoffmann La Roche & Co Ltd, CH-4070 Basel, Switzerland

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 08期

关键词：

D O I：

10.1128/AAC.00225-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Using nonperoxidic analogs of artemisinin and OZ277 (R&11160), the strong in vitro antiplasmodial activities of the latter two compounds were shown to be peroxide bond dependent. In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond independent. These data support the iron-dependent artemisinin alkylation hypothesis.

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页码：2991 / 2993

页数：3

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