Peroxide bond-dependent antiplasmodial specificity of arternisinin and OZ277 (RBx11160)

被引：78

作者：

Kaiser, Marcel

Wittlin, Sergio

Nehrbass-Stuedli, Angela

Dong, Yuxiang

Wang, Xiaofang

Hemphill, Andrew

Matile, Hugues

Brun, Reto

Vennerstrom, Jonathan L.

机构：

[1] Univ Nebraska, Med Ctr, Coll Pharm, Omaha, NE 68198 USA

[2] Swiss Trop Inst, CH-4002 Basel, Switzerland

[3] Univ Bern, Inst Parasitol, CH-3012 Bern, Switzerland

[4] F Hoffmann La Roche & Co Ltd, CH-4070 Basel, Switzerland

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 08期

关键词：

D O I：

10.1128/AAC.00225-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Using nonperoxidic analogs of artemisinin and OZ277 (R&11160), the strong in vitro antiplasmodial activities of the latter two compounds were shown to be peroxide bond dependent. In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond independent. These data support the iron-dependent artemisinin alkylation hypothesis.

引用

收藏

页码：2991 / 2993

页数：3

相关论文

共 43 条

[31] Potent antihematozoan activity of novel bisthiazolium drug T16:: Evidence for inhibition of phosphatidylcholine metabolism in erythrocytes infected with Babesia and Plasmodium spp. [J].

Richier, Eric ;

Biagini, Giancarlo A. ;

Wein, Sharon ;

Boudou, Frederic ;

Bray, Patrick G. ;

Ward, Steve A. ;

Precigout, Eric ;

Calas, Michele ;

Dubremetz, Jean-Francois ;

Vial, Henri J. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (10) :3381-3388

[32] The antimalarial drug artemisinin alkylates heme in infected mice [J].

Robert, A ;

Benoit-Vical, F ;

Claparols, C ;

Meunier, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (38) :13676-13680

[33] Alkylation of heme by the antimalarial drug artemisinin [J].

Robert, A ;

Coppel, Y ;

Meunier, B .

CHEMICAL COMMUNICATIONS, 2002, (05) :414-415

[34] Alkylation of human hemoglobin A0 by the antimalarial drug artemisinin [J].

Selmeczi, K ;

Robert, A ;

Claparols, C ;

Meunier, B .

FEBS LETTERS, 2004, 556 (1-3) :245-248

[35] Synthesis and biological evaluation of pyrazolylnaphthoquinones as new potential antiprotozoal and cytotoxic agents [J].

Sperandeo, NR ;

Brun, R .

CHEMBIOCHEM, 2003, 4 (01) :69-72

[36]

Sullivan DJ, 2003, BIOPOLYMERS, V9, P129, DOI DOI 10.1002/3527600035.BPOL9007

[37] Synthetic peroxides as antimalarials [J].

Tang, YQ ;

Dong, YX ;

Vennerstrom, JL .

MEDICINAL RESEARCH REVIEWS, 2004, 24 (04) :425-448

[38] Antitrypanosomal and antileishmanial activities of flavonoids and their analogues:: In vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies [J].

Tasdemir, D ;

Kaiser, M ;

Brun, R ;

Yardley, V ;

Schmidt, TJ ;

Tosun, F ;

Rüedi, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (04) :1352-1364

[39] Mechanism of antimalarial action of the synthetic trioxoane RBX11160 (OZ277) [J].

Uhlemann, Anne-Catrin ;

Wittlin, Sergio ;

Matile, Hugues ;

Bustamante, Leyla Y. ;

Krishna, Sanjeev .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (02) :667-672

[40] Identification of an antimalarial synthetic trioxolane drug development candidate [J].

Vennerstrom, JL ;

Arbe-Barnes, S ;

Brun, R ;

Charman, SA ;

Chiu, FCK ;

Chollet, J ;

Dong, YX ;

Dorn, A ;

Hunziker, D ;

Matile, H ;

McIntosh, K ;

Padmanilayam, M ;

Tomas, JS ;

Scheurer, C ;

Scorneaux, B ;

Tang, YQ ;

Urwyler, H ;

Wittlin, S ;

Charman, WN .

NATURE, 2004, 430 (7002) :900-904

← 1 2 3 4 5 →