Dystonia update

被引：53

作者：

Bressman, SB

机构：

[1] Beth Israel Med Ctr, Dept Neurol, Bronx, NY 10033 USA

[2] Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10467 USA

来源：

CLINICAL NEUROPHARMACOLOGY | 2000年 / 23卷 / 05期

关键词：

dystonia; dystonia musculorum deformans; Oppenheim's disease; spasmotic torticollis; movement disorders; levodopa-responsive dystonia; anticholinergics; levodopa; botulinum toxin;

D O I：

10.1097/00002826-200009000-00002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Dystonia is a syndrome of sustained muscle spasms of presumed central nervous system origin. Recent advances in molecular biology have permitted clearer understanding of the genetics of various forms of dystonia and suggest pathophysiological deficits at the origin of the clinical signs. Treatment has involved centrally-acting drugs, specifically the anticholinergic medications, as well as peripherally acting agents that block neuromuscular transmission (botulinum toxin). Some forms of dystonia are particularly responsive to levodopa. A systematic approach to the diagnostic and treatment evaluation of dystonic patients permits optimal care for long-term management.

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页码：239 / 251

页数：13

相关论文

共 152 条

[1] Idiopathic torsion dystonia linked to chromosome 8 in two mennonite families [J].

Almasy, L ;

Bressman, SB ;

Raymond, D ;

Kramer, PL ;

Greene, PE ;

Heiman, GA ;

Ford, B ;

Yount, J ;

deLeon, D ;

Chouinard, S ;

SaundersPullman, R ;

Brin, MF ;

Kapoor, RP ;

Jones, AC ;

Shen, H ;

Fahn, S ;

Risch, NJ ;

Nygaard, TG .

ANNALS OF NEUROLOGY, 1997, 42 (04) :670-673

[2] Blepharospasm in association with a lower pontine lesion [J].

Aramideh, M ;

deVisser, BWO ;

Holstege, G ;

Majoie, CBLM ;

Speelman, JD .

NEUROLOGY, 1996, 46 (02) :476-478

[3] Cervical dystonia as the initial presentation of Huntington's disease [J].

Ashizawa, T ;

Jankovic, J .

MOVEMENT DISORDERS, 1996, 11 (04) :457-459

[4]

Augood SJ, 1999, ANN NEUROL, V46, P761, DOI 10.1002/1531-8249(199911)46:5<761::AID-ANA12>3.0.CO

[5]

2-Z

[6] Expression of the early-onset torsion dystonia gene (DYT1) in human brain [J].

Augood, SJ ;

Penney, JB ;

Friberg, IK ;

Breakefield, XO ;

Young, AB ;

Ozelius, LJ ;

Standaert, DG .

ANNALS OF NEUROLOGY, 1998, 43 (05) :669-673

[7] Dopa-responsive dystonia in British patients: New mutations of the GTP-cyclohydrolase I gene and evidence for genetic heterogeneity [J].

Bandmann, O ;

Nygaard, TG ;

Surtees, R ;

Marsden, CD ;

Wood, NW ;

Harding, AE .

HUMAN MOLECULAR GENETICS, 1996, 5 (03) :403-406

[8] Abnormal somatosensory homunculus in dystonia of the hand [J].

Bara-Jimenez, W ;

Catalan, MJ ;

Hallett, M ;

Gerloff, C .

ANNALS OF NEUROLOGY, 1998, 44 (05) :828-831

[9] Dystonia in progressive supranuclear palsy [J].

Barclay, CL ;

Lang, AE .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1997, 62 (04) :352-356

[10] Comparison of transcranial sonography, magnetic resonance imaging, and single photon emission computed tomography findings in idiopathic spasmodic torticollis [J].

Becker, G ;

Naumann, M ;

Scheubeck, M ;

Hofmann, E ;

Deimling, M ;

Lindner, A ;

Gahn, G ;

Reiners, C ;

Toyka, KV ;

Reiners, K .

MOVEMENT DISORDERS, 1997, 12 (01) :79-88

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