Location, location: protein trafficking and lipolysis in adipocytes

被引：99

作者：

Granneman, James G. ^{[1
]}

Moore, Hsiao-Ping H. ^{[2
]}

机构：

[1] Wayne State Univ, Sch Med, Ctr Integrat Metab & Endocrine Res, Detroit, MI 48201 USA

[2] Lawrence Technol Univ, Coll Arts & Sci, Southfield, MI 48075 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2008年 / 19卷 / 01期

关键词：

D O I：

10.1016/j.tem.2007.10.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The storage and mobilization of lipid are central functions of fat cells. Recent proteomic studies suggest that intracellular triglyceride storage droplets are dynamic organelles, and that the signaling events underlying lipid mobilization alter protein trafficking to a specialized subset of these droplets. Here we review recent research that has identified new players in hormone-stimulated lipolysis, and the role of perilipin A, a lipid droplet scaffold protein, in organizing and directing lipolytic protein trafficking.

引用

页码：3 / 9

页数：7

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