Location, location: protein trafficking and lipolysis in adipocytes

被引：99

作者：

Granneman, James G. ^{[1
]}

Moore, Hsiao-Ping H. ^{[2
]}

机构：

[1] Wayne State Univ, Sch Med, Ctr Integrat Metab & Endocrine Res, Detroit, MI 48201 USA

[2] Lawrence Technol Univ, Coll Arts & Sci, Southfield, MI 48075 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2008年 / 19卷 / 01期

关键词：

D O I：

10.1016/j.tem.2007.10.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The storage and mobilization of lipid are central functions of fat cells. Recent proteomic studies suggest that intracellular triglyceride storage droplets are dynamic organelles, and that the signaling events underlying lipid mobilization alter protein trafficking to a specialized subset of these droplets. Here we review recent research that has identified new players in hormone-stimulated lipolysis, and the role of perilipin A, a lipid droplet scaffold protein, in organizing and directing lipolytic protein trafficking.

引用

页码：3 / 9

页数：7

共 67 条

[11] CGI-58/ABHD5 gene is mutated in Dorfman-Chanarin syndrome [J].

Caux, F ;

Ben Selma, Z ;

Laroche, L ;

Prud'homme, JF ;

Fischer, J .

AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2004, 129A (02) :214-214

[12] The lipid-droplet proteome reveals that droplets are a protein-storage depot [J].

Cermelli, Silvia ;

Guo, Yi ;

Gross, Steven P. ;

Welte, Michael A. .

CURRENT BIOLOGY, 2006, 16 (18) :1783-1795

[13] Specific inhibition of hormone-sensitive lipase improves lipid profile while reducing plasma glucose [J].

Claus, TH ;

Lowe, DB ;

Liang, Y ;

Salhanick, AI ;

Lubeski, CK ;

Yang, L ;

Lemoine, L ;

Zhu, J ;

Clairmont, KB .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2005, 315 (03) :1396-1402

[14] Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytes [J].

Clifford, GM ;

Londos, C ;

Kraemer, FB ;

Vernon, RG ;

Yeaman, SJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (07) :5011-5015

[15] Estrogen regulation of adiposity and fuel partitioning - Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways [J].

D'Eon, TM ;

Souza, SC ;

Aronovitz, M ;

Obin, MS ;

Fried, SK ;

Greenberg, AS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (43) :35983-35991

[16] Barrier dysfunction and pathogenesis of neutral lipid storage disease with ichthyosis (Chanarin-Dorfman syndrome) [J].

Demerjian, Marianne ;

Crumrine, Debra A. ;

Milstone, Leonard M. ;

Williams, Mary L. ;

Elias, Peter M. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2006, 126 (09) :2032-2038

[17] Regulation of lipolysis in adipocytes [J].

Duncan, Robin E. ;

Ahmadian, Maryam ;

Jaworski, Kathy ;

Sarkadi-Nagy, Eszter ;

Sul, Hei Sook .

ANNUAL REVIEW OF NUTRITION, 2007, 27 :79-101

[18] MECHANISM OF HORMONE-STIMULATED LIPOLYSIS IN ADIPOCYTES - TRANSLOCATION OF HORMONE-SENSITIVE LIPASE TO THE LIPID STORAGE DROPLET [J].

EGAN, JJ ;

GREENBERG, AS ;

CHANG, MK ;

WEK, SA ;

MOOS, MC ;

LONDOS, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (18) :8537-8541

[19] The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy [J].

Fischer, Judith ;

Lefevre, Caroline ;

Morava, Eva ;

Mussini, Jean-Marie ;

Laforet, Pascal ;

Negre-Salvayre, Anne ;

Lathrop, Mark ;

Salvayre, Robert .

NATURE GENETICS, 2007, 39 (01) :28-30

[20] Analysis of lipolytic protein trafficking and interactions in adipocytes [J].

Granneman, James G. ;

Moore, Hsiao-Ping H. ;

Granneman, Rachel L. ;

Greenberg, Andrew S. ;

Obin, Martin S. ;

Zhu, Zhengxian .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (08) :5726-5735

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