A novel, mouse mammary tumor virus encoded protein with Rev-like properties

被引：79

作者：

Indik, S ^{[1
]}

Günzburg, WH ^{[1
]}

Salmons, B ^{[1
]}

Rouault, F ^{[1
]}

机构：

[1] Austrianova Biotechnol GmbH, A-1210 Vienna, Austria

来源：

VIROLOGY | 2005年 / 337卷 / 01期

关键词：

MMTV; Rem; RNA-expression; regulation; Rec; Rev;

D O I：

10.1016/j.virol.2005.03.040

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have identified a novel, multiple spliced, subgenomic mRNA species in MMTV producing cells of different origin containing an open reading frame encoding a 39-kDa Rev-like protein , Rem (regulator of expression of MMTV). An EGFP-Rem fusion protein is shown to be predominantly in the nucleolus. Further leptomycin B inhibits the nuclear export of nonspliced MMTV transcripts, implicating Rem in nuclear export by the Crm1 pathway in MMTV Rem is thus reminiscent of the Rec protein from the related endogenous human retrovirus, HERV-K. (c) 2005 Elsevier Inc. All rights reserved.

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页码：1 / 6

页数：6

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