MLS - A RETROVIRUS EXPLOITS THE IMMUNE-SYSTEM

被引：240

作者：

ACHAORBEA, H ^{[1
]}

PALMER, E ^{[1
]}

机构：

[1] UNIV COLORADO, HLTH SCI CTR,NATL JEWISH CTR IMMUNOL & RESP MED, DEPT PEDIAT,DIV BASIC SCI, DENVER, CO 80206 USA

来源：

IMMUNOLOGY TODAY | 1991年 / 12卷 / 10期

关键词：

D O I：

10.1016/0167-5699(91)90066-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The identity of minor lymphocyte stimulating (Mls) antigens, endogenous superantigens that can activate, or induce the deletion of, large portions of the T-cell repertoire, has recently been revealed: they are encoded by mouse mammary tumor viruses (MMTV) that have integrated into the germ line as DNA proviruses. As Hans Acha-Orbea and Ed Palmer point out, Mls-mediated modulation may be only the tip of the retrovirus iceberg; already murine leukemia virus (MuLV), with similar superantigen properties, has been discovered.

引用

页码：356 / 361

页数：6

共 66 条

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