Chemical contributions to understanding heparin activity: Synthesis of related sulfated oligosaccharides

被引：72

作者：

Poletti, L

Lay, L

机构：

[1] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy

[2] Univ Milan, Ctr Interdisciplinare Biomol & Applicaz Ind, CISI, I-20133 Milan, Italy

[3] CNR, Ist Sci & Tecnol Mol, I-20133 Milan, Italy

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 2003卷 / 16期

关键词：

carbohydrates; oligosaccharides; glycosylation; heparin; heparan sulfate;

D O I：

10.1002/ejoc.200200721

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Heparin and heparan sulfate are complex polysaccharides that modulate several biological events through the recognition of a number of distinct proteins. Chemical synthesis is a powerful tool to identify the unique binding domains responsible for the specific interactions and to generate potent analogues of the natural sequences. The present review reports the synthetic efforts of the last decade that are focused on the preparation of tailored fragments of these two polymers and analogues thereof. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

引用

页码：2999 / 3024

页数：26

共 161 条

[11] Synthesis of heparin-like antithrombotics having perphosphorylated thrombin binding domains [J].