Local DNA demethylation in vertebrates: how could it be performed and targeted

被引：89

作者：

Kress, C

Thomassin, H

Grange, T

机构：

[1] Univ Paris 06, Inst Jacques Monod, CNRS, F-75251 Paris 05, France

[2] Univ Paris 07, Inst Jacques Monod, CNRS, F-75251 Paris 05, France

来源：

FEBS LETTERS | 2001年 / 494卷 / 03期

关键词：

DNA methylation; DNA demethylation; DNA replication; chromatin; transcription; development;

D O I：

10.1016/S0014-5793(01)02328-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In vertebrates, cytosine methylation is an epigenetic DNA modification that participates in genome stability and gene repression. Methylation patterns are either maintained throughout cell division, or modified by global or local de novo methylation and demethylation, Site-specific demethylation is a rather elusive process that occurs mainly in parallel to gene activation during development. In light of our studies of the glucocorticoid-dependent DNA demethylation of the tyrosine aminotransferase gene, we discuss the potential biochemical mechanisms allowing DNA demethylation and its targeting to specific sequences by transcription factors as well as possible links to DNA replication and chromatin remodelling. (C) 2001 Federation of European Biochemical Societies, Published by Elsevier Science B.V. All rights reserved.

引用

页码：135 / 140

页数：6

共 57 条

[11] Nuclear matrix attachment regions antagonize methylation-dependent repression of long-range enhancer-promoter interactions [J].