Convenient substitution of hydroxypyridines with trifluoroacetaldehyde ethyl hemiacetal

被引：8

作者：

Gong, Y ^{[1
]}

Kato, K ^{[1
]}

Kimoto, H ^{[1
]}

机构：

[1] Natl Ind Res Inst Nagoya, Kita Ku, Nagoya, Aichi 4628510, Japan

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2001年 / 38卷 / 01期

关键词：

D O I：

10.1002/jhet.5570380103

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Thermal substitution of 4-hydroxypyridine 1 with trifluoroacetaldehyde ethyl hemiacetal (TFAE) leads to a moderate yield of 3-(1-hydroxy-2,2,2-trifluoroethyl)-4-hydroxypyridine 7 in the presence of a catalytic amount of anhydrous potassium carbonate. Under similar conditions, several alpha -trifluoromethyl hydroxypyridinemethanols 8-15 are easily prepared from 2- or 3-hydroxypyridines 2-6.

引用

页码：25 / 28

页数：4

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