MicroRNAs in tumorigenesis - A primer

被引:167
作者
Zhang, Wenyong
Dahlberg, James E.
Tam, Wayne
机构
[1] Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA
[2] Univ Wisconsin, Sch Med, Dept Biomol Chem, Madison, WI USA
关键词
D O I
10.2353/ajpath.2007.070070
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
MicroRNAs (miRNAs) are a family of 21- to 25-nucleotide, noncoding small RNAs that primarily function as gene regulators. It is surprising that these tiny molecules, so diverse and consequential in their biological functions, have been hidden for so many years. Thanks to their discovery, cancer research has found a new arena. Aided by innovative molecular techniques, the research of miRNAs in oncology has progressed rapidly in recent years. miRNA abnormalities are becoming an emerging theme in cancer research. Specific functions of miRNAs, many of which are relevant to cancer development, are becoming apparent. The value of miRNAs in cancer classification and prognostication is being explored, and new therapeutic strategies targeting miRNAs are being developed. Because there is great promise that miRNA research will provide breakthroughs in the understanding of cancer pathogenesis and development of new valuable prognostic markers, pathologists should be adequately informed of this rapidly progressing field. Here, we offer a review on the basics of miRNA biology and the emerging role of miRNA in cancer pathogenesis, classification, and prognostication, including highlights of the involvement of specific miRNAs in different tumor types.
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页码:728 / 738
页数:11
相关论文
共 76 条
[1]   Quantitation of microRNAs using a modified Invader assay [J].
Allawi, HT ;
Dahlberg, JE ;
Olson, S ;
Lund, E ;
Olson, M ;
Ma, WP ;
Takova, T ;
Neri, BP ;
Lyamichev, VI .
RNA, 2004, 10 (07) :1153-1161
[2]   Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation [J].
Bagga, S ;
Bracht, J ;
Hunter, S ;
Massirer, K ;
Holtz, J ;
Eachus, R ;
Pasquinelli, AE .
CELL, 2005, 122 (04) :553-563
[3]   Identification by Real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues [J].
Bandres, E. ;
Cubedo, E. ;
Agirre, X. ;
Malumbres, R. ;
Zarate, R. ;
Ramirez, N. ;
Abajo, A. ;
Navarro, A. ;
Moreno, I. ;
Monzo, M. ;
Garcia-Foncillas, J. .
MOLECULAR CANCER, 2006, 5 (1)
[4]   Identification of hundreds of conserved and nonconserved human microRNAs [J].
Bentwich, I ;
Avniel, A ;
Karov, Y ;
Aharonov, R ;
Gilad, S ;
Barad, O ;
Barzilai, A ;
Einat, P ;
Einav, U ;
Meiri, E ;
Sharon, E ;
Spector, Y ;
Bentwich, Z .
NATURE GENETICS, 2005, 37 (07) :766-770
[5]   Dicer is essential for mouse development [J].
Bernstein, E ;
Kim, SY ;
Carmell, MA ;
Murchison, EP ;
Alcorn, H ;
Li, MZ ;
Mills, AA ;
Elledge, SJ ;
Anderson, KV ;
Hannon, GJ .
NATURE GENETICS, 2003, 35 (03) :215-217
[6]   bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila [J].
Brennecke, J ;
Hipfner, DR ;
Stark, A ;
Russell, RB ;
Cohen, SM .
CELL, 2003, 113 (01) :25-36
[7]   Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia [J].
Calin, GA ;
Dumitru, CD ;
Shimizu, M ;
Bichi, R ;
Zupo, S ;
Noch, E ;
Aldler, H ;
Rattan, S ;
Keating, M ;
Rai, K ;
Rassenti, L ;
Kipps, T ;
Negrini, M ;
Bullrich, F ;
Croce, CM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (24) :15524-15529
[8]   Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers [J].
Calin, GA ;
Sevignani, C ;
Dan Dumitru, C ;
Hyslop, T ;
Noch, E ;
Yendamuri, S ;
Shimizu, M ;
Rattan, S ;
Bullrich, F ;
Negrini, M ;
Croce, CM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (09) :2999-3004
[9]   A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia [J].
Calin, GA ;
Ferracin, M ;
Cimmino, A ;
Di Leva, G ;
Shimizu, M ;
Wojcik, SE ;
Iorio, MV ;
Visone, R ;
Sever, NI ;
Fabbri, M ;
Iuliano, R ;
Palumbo, T ;
Pichiorri, F ;
Roldo, C ;
Garzon, R ;
Sevignani, C ;
Rassenti, L ;
Alder, H ;
Volinia, S ;
Liu, CG ;
Kipps, TJ ;
Negrini, M ;
Croce, CM .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (17) :1793-1801
[10]   A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA) [J].
Castoldi, M ;
Schmidt, S ;
Benes, V ;
Noerholm, M ;
Kulozik, AE ;
Hentze, MW ;
Muckenthaler, MU .
RNA, 2006, 12 (05) :913-920