Epigenomic mapping in Arabidopsis using tiling microarrays

被引：33

作者：

Martienssen, RA

Doerge, RW

Colot, V

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

[2] Purdue Univ, Dept Stat, W Lafayette, IN 47907 USA

[3] UEVE, CNRS, INRA, URGV, F-91057 Evry, France

来源：

CHROMOSOME RESEARCH | 2005年 / 13卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Arabidopsis; epigenetics; heterochromatin; histone; methylation; tiling microarrays;

D O I：

10.1007/s10577-005-1507-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In addition to genetic information, chromosomes transmit epigenetic information from cell to cell during division, and sometimes from generation to generation. While genetic information is encoded directly in the DNA sequence, epigenetic information is not, although it is usually associated with specific chromosomal regions. Epigenetic modifications in plants include cytosine methylation as well as modification of histones and other chromosomal proteins. Small interfering RNA play major roles in targeting these modifications to specific regions. Genomic tiling microarrays are powerful tools for analysing epigenetic information, and we review their application in building epigenomic maps in the model plant, Arabidopsis.

引用

页码：299 / 308

页数：10

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