Pharmacological study of the novel compound FLZ against experimental Parkinson's models and its active mechanism

被引：27

作者：

Feng, WH ^{[1
]}

Wei, HL ^{[1
]}

Liu, GT ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, Beijing 100037, Peoples R China

来源：

MOLECULAR NEUROBIOLOGY | 2005年 / 31卷 / 1-3期

关键词：

Parkinson's disease; dopaminergic neurons; oxidative stress; apoptosis; compound FLZ; MPTP; dopamine;

D O I：

10.1385/MN:31:1-3:295

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

FLZ is a synthetic new derivative of squamosamide. Pharmacological study found that FLZ given orally improved the abnormal behavior caused by the functional disturbance of dopaminergic and cholinergic neurons in mice. FLZ significantly increased the content of dopamine and its metabolites in striatum in MPTP model mice. FLZ also remarkably protected dopaminergic PC-12 cells against dopamine and MPP+ induced injury and apoptosis in vitro. The compound inhibited the formation of dopamine-melanin and protein polymers. Additionally, FLZ inhibited cytochrome-c release from mitochondria and caspase-3 activation by dopamine in PC-12 cells. The above results suggest that compound FLZ possesses anti-PD activity through neuroprotection.

引用

页码：295 / 300

页数：6

共 26 条

[1] Parkin and α-synuclein:: Opponent actions in the pathogenesis of Parkinson's disease [J].

Baptista, MJ ;

Cookson, MR ;

Miller, DW .

NEUROSCIENTIST, 2004, 10 (01) :63-72

[2] Neurodegenerative diseases and oxidative stress [J].

Barnham, KJ ;

Masters, CL ;

Bush, AI .

NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (03) :205-214

[3]

Beal MF, 2003, ANN NY ACAD SCI, V991, P120

[4]

Buege JA, 1978, METHOD ENZYMOL, V52, P301

[5] CHRONIC L-DOPA TREATMENT IN THE UNILATERAL 6-OHDA RAT - EVIDENCE FOR BEHAVIORAL SENSITIZATION AND BIOCHEMICAL TOLERANCE [J].

CAREY, RJ .

BRAIN RESEARCH, 1991, 568 (1-2) :205-214

[6] New insights into Parkinson's disease [J].

Chung, KKK ;

Dawson, VL ;

Dawson, TM .

JOURNAL OF NEUROLOGY, 2003, 250 (Suppl 3) :15-24

[7] Parkinson's disease: Mechanisms and models [J].

Dauer, W ;

Przedborski, S .

NEURON, 2003, 39 (06) :889-909

[8] Molecular pathways of neurodegeneration in Parkinson's disease [J].

Dawson, TM ;

Dawson, VL .

SCIENCE, 2003, 302 (5646) :819-822

[9] A NEW AND RAPID COLORIMETRIC DETERMINATION OF ACETYLCHOLINESTERASE ACTIVITY [J].

ELLMAN, GL ;

COURTNEY, KD ;

ANDRES, V ;

FEATHERSTONE, RM .

BIOCHEMICAL PHARMACOLOGY, 1961, 7 (02) :88-&

[10]

ERGO AC, 2003, NEUROCHEM RES, V28, P1563

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