Iron and LDL-oxidation in atherogenesis

被引：40

作者：

Yuan, XM ^{[1
]}

Brunk, UT

机构：

[1] Linkoping Univ, Fac Hlth Sci, Dept Pathol 2, S-58185 Linkoping, Sweden

[2] Linkoping Univ, Clin Res Ctr, S-58185 Linkoping, Sweden

来源：

APMIS | 1998年 / 106卷 / 09期

关键词：

atherosclerosis; iron; LDL; lysosomes; macrophages;

D O I：

10.1111/j.1699-0463.1998.tb00229.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It has been proposed that the development of atherosclerosis may be linked to the size of the body iron stores. The exact role of iron in the initiation and progression of atherogenesis is, however, still unknown. As a result of increasing support for the LDL-oxidation hypothesis, much additional knowledge about the relation between iron and atherosclerosis has recently been gained. This review presents the current evidence on the role of iron - being a potent catalyst of oxidative reactions - and macrophage-mediated LDL-oxidation in atherogenesis. The authors hypothesize that iron, as a possible central intermediary, may play an important role in cell-mediated LDL-oxidation.

引用

页码：825 / 842

页数：18

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