Microfluidics for drug discovery and development: From target selection to product lifecycle management

被引：255

作者：

Kang, Lifeng ^{[1
,2
,4
]}

Chung, Bong Geun ^{[1
,2
]}

Langer, Robert ^{[1
,3
]}

Khademhosseini, Ali ^{[1
,2
]}

机构：

[1] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[2] Harvard Univ, Sch Med, Dept Med, Brigham & Womens Hosp,Ctr Biomed Engn, Cambridge, MA 02139 USA

[3] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[4] Natl Univ Singapore, Dept Pharm, Singapore 117548, Singapore

来源：

DRUG DISCOVERY TODAY | 2008年 / 13卷 / 1-2期

关键词：

D O I：

10.1016/j.drudis.2007.10.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Microfluidic technologies' ability to miniaturize assays and increase experimental throughput have generated significant interest in the drug discovery and development domain. These characteristics make microfluidic systems a potentially valuable tool for many drug discovery and development applications. Here, we review the recent advances of microfluidic devices for drug discovery and development and highlight their applications in different stages of the process, including target selection, lead identification, preclinical tests, clinical trials, chemical synthesis, formulations studies and product management.

引用

页码：1 / 13

页数：13

共 106 条

[1] The integration of pharmacokinetics and pharmacodynamics: Understanding dose-response [J].

Abdel-Rahman, SM ;

Kauffman, RE .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2004, 44 :111-136

[2] Production of arrays of chemically distinct nanolitre plugs via repeated splitting in microfluidic devices [J].

Adamson, David N. ;

Mustafi, Debarshi ;

Zhang, John X. J. ;

Zheng, Bo ;

Ismagilov, Rustem F. .

LAB ON A CHIP, 2006, 6 (09) :1178-1186

[3] Phase knowledge enables rational screens for protein crystallization [J].

Anderson, Megan J. ;

Hansen, Carl L. ;

Quake, Stephen R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (45) :16746-16751

[4] Five years on ... and four challenges for the pharmaceutical industry [J].

不详 .

NATURE REVIEWS DRUG DISCOVERY, 2007, 6 (01) :3-3

[5]

[Anonymous], DRUG DISC DEV UND R

[6] Trends in the development of microfluidic cell biochips for in vitro hepatotoxicity [J].

Baudoin, Regis ;

Corlu, Anne ;

Griscom, Laurent ;

Legallais, Cecile ;

Leclerc, Eric .

TOXICOLOGY IN VITRO, 2007, 21 (04) :535-544

[7] Hit and lead generation:: Beyond high-throughput screening [J].

Bleicher, KH ;

Böhm, HJ ;

Müller, K ;

Alanine, AI .

NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (05) :369-378

[8]

Bohacek RS, 1996, MED RES REV, V16, P3, DOI 10.1002/(SICI)1098-1128(199601)16:1<3::AID-MED1>3.3.CO

[9]

2-D

[10] Drug delivery - Controlling the flow [J].

Brazil, M .

NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (07) :510-510

← 1 2 3 4 5 6 7 8 9 10 →