Microfluidics for drug discovery and development: From target selection to product lifecycle management

被引：255

作者：

Kang, Lifeng ^{[1
,2
,4
]}

Chung, Bong Geun ^{[1
,2
]}

Langer, Robert ^{[1
,3
]}

Khademhosseini, Ali ^{[1
,2
]}

机构：

[1] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[2] Harvard Univ, Sch Med, Dept Med, Brigham & Womens Hosp,Ctr Biomed Engn, Cambridge, MA 02139 USA

[3] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[4] Natl Univ Singapore, Dept Pharm, Singapore 117548, Singapore

来源：

DRUG DISCOVERY TODAY | 2008年 / 13卷 / 1-2期

关键词：

D O I：

10.1016/j.drudis.2007.10.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Microfluidic technologies' ability to miniaturize assays and increase experimental throughput have generated significant interest in the drug discovery and development domain. These characteristics make microfluidic systems a potentially valuable tool for many drug discovery and development applications. Here, we review the recent advances of microfluidic devices for drug discovery and development and highlight their applications in different stages of the process, including target selection, lead identification, preclinical tests, clinical trials, chemical synthesis, formulations studies and product management.

引用

页码：1 / 13

页数：13

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