Paradigm shift in neuroprotective drug development: clinically tolerated NMDA receptor inhibition by memantine

被引:59
作者
Lipton, SA
Chen, HSV
机构
[1] Burnham Inst, Ctr Neurosci & Aging, La Jolla, CA 92037 USA
[2] Univ Calif San Diego, La Jolla, CA 92037 USA
[3] Scripps Res Inst, La Jolla, CA 92037 USA
关键词
D O I
10.1038/sj.cdd.4401344
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:18 / 20
页数:3
相关论文
共 15 条
[1]   APOPTOSIS AND NECROSIS - 2 DISTINCT EVENTS INDUCED, RESPECTIVELY, BY MILD AND INTENSE INSULTS WITH N-METHYL-D-ASPARTATE OR NITRIC-OXIDE SUPEROXIDE IN CORTICAL CELL-CULTURES [J].
BONFOCO, E ;
KRAINC, D ;
ANKARCRONA, M ;
NICOTERA, P ;
LIPTON, SA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) :7162-7166
[2]   Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation [J].
Chen, HSV ;
Wang, YF ;
Rayudu, PV ;
Edgecomb, P ;
Neill, JC ;
Segal, MM ;
Lipton, SA ;
Jensen, FE .
NEUROSCIENCE, 1998, 86 (04) :1121-1132
[3]  
CHEN HSV, 1992, J NEUROSCI, V12, P4427
[4]   Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: Uncompetitive antagonism [J].
Chen, HSV ;
Lipton, SA .
JOURNAL OF PHYSIOLOGY-LONDON, 1997, 499 (01) :27-46
[5]   Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation [J].
Choi, YB ;
Tenneti, L ;
Le, DA ;
Ortiz, J ;
Bai, G ;
Chen, HSV ;
Lipton, SA .
NATURE NEUROSCIENCE, 2000, 3 (01) :15-21
[6]   Pathobiology of ischaemic stroke: an integrated view [J].
Dirnagl, U ;
Iadecola, C ;
Moskowitz, MA .
TRENDS IN NEUROSCIENCES, 1999, 22 (09) :391-397
[7]   Potential and current use of N-methyl-D-aspartate (NMDA) receptor antagonists in diseases of aging [J].
Le, DA ;
Lipton, SA .
DRUGS & AGING, 2001, 18 (10) :717-724
[8]   EFFECT OF NITRIC-OXIDE PRODUCTION ON THE REDOX MODULATORY SITE OF THE NMDA RECEPTOR CHANNEL COMPLEX [J].
LEI, SZ ;
PAN, ZH ;
AGGARWAL, SK ;
CHEN, HSV ;
HARTMAN, J ;
SUCHER, NJ ;
LIPTON, SA .
NEURON, 1992, 8 (06) :1087-1099
[9]  
LIPTON SA, 1994, NEW ENGL J MED, V330, P613
[10]   PROSPECTS FOR CLINICALLY TOLERATED NMDA ANTAGONISTS - OPEN-CHANNEL BLOCKERS AND ALTERNATIVE REDOX STATES OF NITRIC-OXIDE [J].
LIPTON, SA .
TRENDS IN NEUROSCIENCES, 1993, 16 (12) :527-532