A singular chromosome

被引:8
作者
Hurles, ME
Jobling, MA
机构
[1] Univ Cambridge, McDonald Inst Archaeol Res, Cambridge CB2 3ER, England
[2] Univ Leicester, Dept Genet, Leicester LE1 7RH, Leics, England
基金
英国惠康基金;
关键词
D O I
10.1038/ng0703-246
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The human Y chromosome is the first constitutively haploid metazoan chromosome to be sequenced. It has a unique genomic landscape with a complex evolutionary history that has endowed it with few genes but many nearly identical dispersed repeats that underlie the structural fluidity of this unusual chromosome.
引用
收藏
页码:246 / 247
页数:2
相关论文
共 16 条
[1]   Recent segmental duplications in the human genome [J].
Bailey, JA ;
Gu, ZP ;
Clark, RA ;
Reinert, K ;
Samonte, RV ;
Schwartz, S ;
Adams, MD ;
Myers, EW ;
Li, PW ;
Eichler, EE .
SCIENCE, 2002, 297 (5583) :1003-1007
[2]   Divergent outcomes of intrachromosomal recombination on the human Y chromosome: male infertility and recurrent polymorphism [J].
Blanco, P ;
Shlumukova, M ;
Sargent, CA ;
Jobling, MA ;
Affara, N ;
Hurles, ME .
JOURNAL OF MEDICAL GENETICS, 2000, 37 (10) :752-758
[3]   Duplications of the AZFa region of the human Y chromosome are mediated by homologous recombination between HERVs and are compatible with male fertility [J].
Bosch, E ;
Jobling, MA .
HUMAN MOLECULAR GENETICS, 2003, 12 (03) :341-347
[4]   The evolution of dominance [J].
Fisher, RA .
BIOLOGICAL REVIEWS AND BIOLOGICAL PROCEEDINGS OF THE CAMBRIDGE PHILOSOPHICAL SOCIETY, 1931, 6 (04) :345-368
[5]   Simian Y Chromosomes:: species-specific rearrangements of DAZ, RBM, and TSPY versus contiguity of PAR and SRY [J].
Gläser, B ;
Grützner, F ;
Willmann, U ;
Stanyon, R ;
Arnold, N ;
Taylor, K ;
Rietschel, W ;
Zeitler, S ;
Toder, R ;
Schempp, W .
MAMMALIAN GENOME, 1998, 9 (03) :226-231
[6]   Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p [J].
Guy, J ;
Hearn, T ;
Crosier, M ;
Mudge, J ;
Viggiano, L ;
Koczan, D ;
Thiesen, HJ ;
Bailey, JA ;
Horvath, JE ;
Eichler, EE ;
Earthrowl, ME ;
Deloukas, P ;
French, L ;
Rogers, J ;
Bentley, D ;
Jackson, MS .
GENOME RESEARCH, 2003, 13 (02) :159-172
[7]   MALE DEVELOPMENT OF CHROMOSOMALLY FEMALE MICE TRANSGENIC FOR SRY [J].
KOOPMAN, P ;
GUBBAY, J ;
VIVIAN, N ;
GOODFELLOW, P ;
LOVELLBADGE, R .
NATURE, 1991, 351 (6322) :117-121
[8]   Four evolutionary strata on the human X chromosome [J].
Lahn, BT ;
Page, DC .
SCIENCE, 1999, 286 (5441) :964-967
[9]  
Ohno S., 1967, SEX CHROMOSOMES SEX
[10]   The use of spermHALO-FISH to determine DAZ gene copy number [J].
Repping, S ;
de Vries, JWA ;
van Daalen, SKM ;
Korver, CM ;
Leschot, NJ ;
van der Veen, F .
MOLECULAR HUMAN REPRODUCTION, 2003, 9 (04) :183-188