Carbonyl stress and diabetic complications

被引：36

作者：

Miyata, T ^{[1
]}

Ishikawa, N

de Strihou, CV

机构：

[1] Tokai Univ, Sch Med, Inst Med Sci, Kanagawa 2591193, Japan

[2] Tokai Univ, Sch Med, Dept Med, Kanagawa 2591193, Japan

[3] Catholic Univ Louvain, Serv Nephrol, Brussels, Belgium

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2003年 / 41卷 / 09期

关键词：

carbonyl stress; oxidative stress; diabetes mellitus; advanced glycosylation end-products;

D O I：

10.1515/CCLM.2003.178

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Advanced glycation irreversibly and progressively modifies proteins over time and yields the advanced glycation endproducts (AGE). AGEs are thought to contribute to the development of atherosclerosis and of diabetic and uremic complications. Their inhibition has thus become a therapeutic goal. In this article, we discuss the role of various reactive carbonyl compound (RCOs) in the genesis of AGEs, postulate the existence of carbonyl stress in complicated diabetes and, finally, discuss therapeutic perspectives.

引用

页码：1150 / 1158

页数：9

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