The sympathetic nervous system is involved in variant Creutzfeldt-Jakob disease

被引：60

作者：

Haïk, S ^{[1
]}

Faucheux, BA

Sazdovitch, V

Privat, N

Kemeny, JL

Perret-Liaudet, A

Hauw, JJ

机构：

[1] Hop La Pitie Salpetriere, Assoc Claude Bernard, Raymond Escourolle Neuropathol Lab, F-75013 Paris, France

[2] Hop La Pitie Salpetriere, INSERM, U360, F-75013 Paris, France

[3] G Montpied Hosp, Dept Pathol Anat, F-63000 Clermont Ferrand, France

[4] Neurol Hosp, Biochem Lab, Ctr Diagnost & Treatment Prions Dis, F-69003 Lyon, France

来源：

NATURE MEDICINE | 2003年 / 9卷 / 09期

关键词：

D O I：

10.1038/nm922

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prion epizoonoses spread from animals consumed by humans raise the question of which pathways lead to prion neuroinvasion after oral exposure of humans. Here we show that neurons of sympathetic ganglia of patients with variant Creutzfeldt-Jakob disease (vCJD) accumulate the abnormal isoform of the protein prion. This observation shows the involvement of the sympathetic nervous system in the pathogenesis of vCJD and suggests a role for GUT-associated sympathetic neurons in prion propagation in humans after oral contamination.

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页码：1121 / 1123

页数：3

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