Escapable and inescapable stress differentially alter extracellular levels of 5-HT in the basolateral amygdala of the rat

被引：171

作者：

Amat, J

Matus-Amat, P

Watkins, LR

Maier, SF

机构：

[1] Univ Colorado, Dept Psychol, Boulder, CO 80309 USA

[2] Inst Venezolano Invest, CBB, Caracas, Venezuela

[3] Cent Univ Venezuela, Inst Expt Med, Caracas, Venezuela

来源：

BRAIN RESEARCH | 1998年 / 812卷 / 1-2期

关键词：

learned helplessness; inescapable shock; stressor controllability; 5-HT; 5-HIAA; in vivo microdialysis; amygdala;

D O I：

10.1016/S0006-8993(98)00960-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of escapable and yoked inescapable electric tailshocks on extracellular levels of serotonin (5-HT) in the basolateral amygdala were measured by in vivo microdialysis. Inescapable, but not escapable, shock increased extracellular 5-HT in the amygdala relative to restrained controls. Basal levels of 5-HT were elevated 24 h after inescapable shock, and previously inescapably shocked subjects exhibited an exaggerated 5-HT response to two brief footshocks. Levels of extracellular 5-HIAA did not follow any particular pattern and were not correlated with the changes in 5-HT. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：113 / 120

页数：8

共 58 条

[1] Comparative study in the rat of the actions of different types of stress on the release of 5-HT in raphe nuclei and forebrain areas [J].