Transient state kinetic investigation of ferritin iron release

被引：31

作者：

Ciasca, G. ^{[2
,3
]}

Papi, M. ^{[1
]}

Chiarpotto, M. ^{[4
]}

Rodio, M. ^{[2
]}

Campi, G. ^{[5
]}

Rossi, C. ^{[4
]}

De Sole, P. ^{[4
]}

Bianconi, A. ^{[2
]}

机构：

[1] Catholic Univ, Inst Phys, I-00168 Rome, Italy

[2] Univ Roma La Sapienza, Dept Phys, I-00185 Rome, Italy

[3] CNR, Inst Photon & Nanotechnol IFN, I-00156 Rome, Italy

[4] Catholic Univ, Dept Clin Biochem, I-00168 Rome, Italy

[5] CNR, Inst Crystallog, I-00016 Rome, Italy

来源：

APPLIED PHYSICS LETTERS | 2012年 / 100卷 / 07期

关键词：

REMOVAL;

D O I：

10.1063/1.3685706

中图分类号：

O59 [应用物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

Increased iron concentration in tissues appears to be a factor in the genesis and development of inflammatory and degenerative diseases. By means of real-time small angle x-ray scattering measurements, we studied the kinetics of iron release from the ferritin inorganic core as a function of time and distance from the iron core centre. Accordingly, the iron release process follows a three step model: (i) a defect nucleation in the outer part of the mineral core, (ii) the diffusion of the reducing agent towards the inner part of the core, and (iii) the erosion of the core from the inner to the outer part. (C) 2012 American Institute of Physics. [doi:10.1063/1.3685706]

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