CLC chloride channels and transporters

被引：106

作者：

Jentsch, TJ ^{[1
]}

Neagoe, L ^{[1
]}

Scheel, O ^{[1
]}

机构：

[1] Univ Hamburg, ZMNH, Zentrum Mol Neurobiol, D-20246 Hamburg, Germany

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2005年 / 15卷 / 03期

关键词：

D O I：

10.1016/j.conb.2005.05.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

CLC proteins are found in cells from prokaryotes to mammals and perform functions in plasma membranes and intracellular vesicles. Several genetic human diseases and mouse models underscore their broad physiological functions in mammals. These functions range from the control of excitability to transepithelial transport, endocytotic trafficking and acidification of synaptic vesicles. The recent crystallization of bacterial CLC proteins gave surprising insights into CLC Cl--channel permeation and gating and provides an excellent basis for structure-function studies. Surprisingly, the CLC from Escherichia coli functions as a Cl-/H+ exchanger, thus demonstrating the thin line separating transporters and channels.

引用

页码：319 / 325

页数：7

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