CLC chloride channels and transporters

被引：106

作者：

Jentsch, TJ ^{[1
]}

Neagoe, L ^{[1
]}

Scheel, O ^{[1
]}

机构：

[1] Univ Hamburg, ZMNH, Zentrum Mol Neurobiol, D-20246 Hamburg, Germany

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2005年 / 15卷 / 03期

关键词：

D O I：

10.1016/j.conb.2005.05.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

CLC proteins are found in cells from prokaryotes to mammals and perform functions in plasma membranes and intracellular vesicles. Several genetic human diseases and mouse models underscore their broad physiological functions in mammals. These functions range from the control of excitability to transepithelial transport, endocytotic trafficking and acidification of synaptic vesicles. The recent crystallization of bacterial CLC proteins gave surprising insights into CLC Cl--channel permeation and gating and provides an excellent basis for structure-function studies. Surprisingly, the CLC from Escherichia coli functions as a Cl-/H+ exchanger, thus demonstrating the thin line separating transporters and channels.

引用

页码：319 / 325

页数：7

共 55 条

[31] Loss of the CIC-7 chloride channel leads to osteopetrosis in mice and man [J].

Kornak, U ;

Kasper, D ;

Bösl, MR ;

Kaiser, E ;

Schweizer, M ;

Schulz, A ;

Friedrich, W ;

Delling, G ;

Jentsch, TJ .

CELL, 2001, 104 (02) :205-215

[32] Two physically distinct pores in the dimeric CIC-0 chloride channel [J].

Ludewig, U ;

Pusch, M ;

Jentsch, TJ .

NATURE, 1996, 383 (6598) :340-343

[33] Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel [J].

Matsumura, Y ;

Uchida, S ;

Kondo, Y ;

Miyazaki, H ;

Ko, SBH ;

Hayama, A ;

Morimoto, T ;

Liu, W ;

Arisawa, M ;

Sasaki, S ;

Marumo, F .

NATURE GENETICS, 1999, 21 (01) :95-98

[34] Homodimeric architecture of a CIC-type chloride ion channel [J].

Middleton, RE ;

Pheasant, DJ ;

Miller, C .

NATURE, 1996, 383 (6598) :337-340

[35] DIMERIC STRUCTURE OF SINGLE CHLORIDE CHANNELS FROM TORPEDO ELECTROPLAX [J].

MILLER, C ;

WHITE, MM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (09) :2772-2775

[36] Anion pathway and potential energy profiles along curvilinear bacterial ClC Cl- pores:: Electrostatic effects of charged residues [J].

Miloshevsky, GV ;

Jordan, PC .

BIOPHYSICAL JOURNAL, 2004, 86 (02) :825-835

[37] The chloride channel ClC-4 contributes to endosomal acidification and trafficking [J].

Mohammad-Panah, R ;

Harrison, R ;

Dhani, S ;

Ackerley, C ;

Huan, LJ ;

Wang, YC ;

Bear, CE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (31) :29267-29277

[38] Functional evaluation of human ClC-2 chloride channel mutations associated with idiopathic generalized epilepsies [J].

Niemeyer, MI ;

Yusef, YR ;

Cornejo, I ;

Flores, CA ;

Sepúlveda, FV ;

Cid, LP .

PHYSIOLOGICAL GENOMICS, 2004, 19 (01) :74-83

[39] ClC-3B, a novel ClC-3 splicing variant that interacts with EBP50 and facilitates expression of CFTR-regulated ORCC [J].

Ogura, T ;

Furukawa, T ;

Toyozaki, T ;

Yamada, K ;

Zheng, YJ ;

Katayama, Y ;

Nakaya, H ;

Inagaki, N .

FASEB JOURNAL, 2002, 16 (06) :863-+

[40] Molecular determinants of differential pore blocking of kidney CLC-K chloride channels [J].

Picollo, A ;

Liantonio, A ;

Didonna, MP ;

Elia, L ;

Camerino, DC ;

Pusch, M .

EMBO REPORTS, 2004, 5 (06) :584-589

← 1 2 3 4 5 6 →