Small RNA guides for de novo DNA methylation in mammalian germ cells

被引：125

作者：

Aravin, Alexei A. ^{[2
]}

Bourc'his, Deborah ^{[1
]}

机构：

[1] Univ Paris 07, INSERM, U741, F-75251 Paris 05, France

[2] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

GENES & DEVELOPMENT | 2008年 / 22卷 / 08期

关键词：

piwi; piRNA; retrotransposon; DNA methylation; spermatogenesis;

D O I：

10.1101/gad.1669408

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Germline genomic methylation is essential for gamete identity and integrity in mammals. The study by Kuramochi-Miyagawa and colleagues (pp. 908-917) in the previous issue of Genes & Development links the process of DNA methylation-dependent repression of retrotranspons with the presence of piwi-interacting RNAs (piRNAs) in fetal male germ cells undergoing de novo methylation.

引用

页码：970 / 975

页数：6

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