90-day repeated-dose toxicity study of licorice flavonoid oil (LFO) in rats

被引：28

作者：

Nakagawa, K. ^{[2
]}

Kitano, M. ^{[1
]}

Kishida, H. ^{[1
]}

Hidaka, T. ^{[2
]}

Nabae, K. ^{[3
]}

Kawabe, M. ^{[3
]}

Hosoe, K. ^{[1
]}

机构：

[1] Kaneka Corp, Corp Res & Dev Div, Frontier Biochem & Med Res Labs, Pharmacol & Toxicol Lab, Takasago, Hyogo 6768688, Japan

[2] Kaneka Corp, Healthcare Prod Business Unit, Funct Food Ingredients Div, Kita Ku, Osaka 5308288, Japan

[3] DIMS Inst Med Sci Inc, Aichi 4910113, Japan

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2008年 / 46卷 / 07期

关键词：

licorice flavonoid oil; Glycyrrhiza glabra; rat; subchronic toxicity; NOAEL;

D O I：

10.1016/j.fct.2008.03.015

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Licorice flavonoid oil (LFO) is a new functional food ingredient consisting of licorice hydrophobic polyphenols in medium-chain triglycerides (MCT). As part of a safety evaluation, a 90-day oral toxicity study in rats was conducted using an LFO concentrate solution (2.90% glabridin). Male and female animals were assigned to one of 12 groups (10 males or females per group) and received corn oil (negative control), MCT (vehicle control), or 400, 600, 800 or 1600 mg/kg of the LFO concentrate solution.In conclusion, LFO concentrate solution induced an anticoagulation effect in both sexes, although there was a clear sex difference. Based on thezse findings, it is concluded that the no-observed-adverse-effect level (NOAEL) for the LFO concentrate solution is estimated to be 800 mg/kg/day for female rats, and approximately 400 mg/kg/day for male rats. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2349 / 2357

页数：9

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