90-day repeated-dose toxicity study of licorice flavonoid oil (LFO) in rats

被引：28

作者：

Nakagawa, K. ^{[2
]}

Kitano, M. ^{[1
]}

Kishida, H. ^{[1
]}

Hidaka, T. ^{[2
]}

Nabae, K. ^{[3
]}

Kawabe, M. ^{[3
]}

Hosoe, K. ^{[1
]}

机构：

[1] Kaneka Corp, Corp Res & Dev Div, Frontier Biochem & Med Res Labs, Pharmacol & Toxicol Lab, Takasago, Hyogo 6768688, Japan

[2] Kaneka Corp, Healthcare Prod Business Unit, Funct Food Ingredients Div, Kita Ku, Osaka 5308288, Japan

[3] DIMS Inst Med Sci Inc, Aichi 4910113, Japan

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2008年 / 46卷 / 07期

关键词：

licorice flavonoid oil; Glycyrrhiza glabra; rat; subchronic toxicity; NOAEL;

D O I：

10.1016/j.fct.2008.03.015

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Licorice flavonoid oil (LFO) is a new functional food ingredient consisting of licorice hydrophobic polyphenols in medium-chain triglycerides (MCT). As part of a safety evaluation, a 90-day oral toxicity study in rats was conducted using an LFO concentrate solution (2.90% glabridin). Male and female animals were assigned to one of 12 groups (10 males or females per group) and received corn oil (negative control), MCT (vehicle control), or 400, 600, 800 or 1600 mg/kg of the LFO concentrate solution.In conclusion, LFO concentrate solution induced an anticoagulation effect in both sexes, although there was a clear sex difference. Based on thezse findings, it is concluded that the no-observed-adverse-effect level (NOAEL) for the LFO concentrate solution is estimated to be 800 mg/kg/day for female rats, and approximately 400 mg/kg/day for male rats. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2349 / 2357

页数：9

共 17 条

[11]

SMITH LJ, 1987, HAEMOSTASIS, V17, P206

[12] Licorice flavonoid oil effects body weight loss by reduction of body fat mass in overweight subjects [J].

Tominaga, Yuji ;

Mae, Tatsumasa ;

Kitano, Mitsuaki ;

Sakamoto, Yoshiro ;

Ikematsu, Hideyuki ;

Nakagawa, Kaku .

JOURNAL OF HEALTH SCIENCE, 2006, 52 (06) :672-683

[13] Review of the toxicologic properties of medium-chain triglycerides [J].

Traul, KA ;

Driedger, A ;

Ingle, DL ;

Nakhasi, D .

FOOD AND CHEMICAL TOXICOLOGY, 2000, 38 (01) :79-98

[14]

Watt Barbara E, 2005, Toxicol Rev, V24, P259, DOI 10.2165/00139709-200524040-00005

[15] A 91-DAY FEEDING STUDY IN RATS WITH CAPRENIN [J].

WEBB, DR ;

WOOD, FE ;

BERTRAM, TA ;

FORTIER, NE .

FOOD AND CHEMICAL TOXICOLOGY, 1993, 31 (12) :935-946

[16] AN INVESTIGATION OF SEX-LINKED DIFFERENCES TO THE TOXIC AND TO THE PHARMACOLOGICAL ACTIONS OF DIFENACOUM - STUDIES IN MICE AND RATS [J].

WINN, MJ ;

CLEGG, JAD ;

PARK, BK .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1987, 39 (03) :219-222

[17] MECHANISM OF THE ANTICOAGULANT EFFECT OF WARFARIN AS EVALUATED IN RABBITS BY SELECTIVE DEPRESSION OF INDIVIDUAL PROCOAGULANT VITAMIN-K-DEPENDENT CLOTTING FACTORS [J].

ZIVELIN, A ;

RAO, LVM ;

RAPAPORT, SI .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (05) :2131-2140

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