Neonatal complications of preterm premature rupture of membranes - Pathophysiology and management

Midtrimester premature rupture of membranes is an infrequent, but serious pregnancy complication that puts the fetus at risk for preterm delivery and associated neonatal problems. Unique neonatal complications may occur with prolonged latency. Extended fetal exposure to oligohydramnios beginning early in pregnancy may result in disturbed lung growth, resulting in severe respiratory distress in the newborn, often associated with skeletal deformations. Guidance for early neonatal management is presented, based on pathophysiologic considerations.