Regulation of the rat liver carnitine palmitoyltransferase I gene transcription by thyroid hormone

被引：10

作者：

Barrero, MJ ^{[1
]}

Marrero, PF ^{[1
]}

Haro, D ^{[1
]}

机构：

[1] Univ Barcelona, Fac Farm, Sch Pharm, Dept Biochem & Mol Biol, E-08028 Barcelona, Spain

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 279卷 / 01期

关键词：

D O I：

10.1006/bbrc.2000.3893

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

L-CPT I isotype is the main locus of control for liver LCFA oxidation. T3 levels have been described as controlling L-CPT I gene expression, and in this paper we demonstrate that rat liver CPT I promoter responds to T3. Using deleted reporter constructs we located the thyroid hormone-responsive element between -2935 and -2918, consisting of a DR4. This response is mediated by the binding of the thyroid to this sequence as a monomer, homodimer, or heterodimer with RXR. (C) 2000 Academic Press.

引用

页码：81 / 88

页数：8

共 31 条

[1] DEVELOPMENTAL-CHANGES IN CARNITINE PALMITOYLTRANSFERASE-I AND PALMITOYLTRANSFERASE-II GENE-EXPRESSION IN INTESTINE AND LIVER OF SUCKLING RATS [J].

ASINS, G ;

SERRA, D ;

ARIAS, G ;

HEGARDT, FG .

BIOCHEMICAL JOURNAL, 1995, 306 :379-384

[2]

Ausubel FM, 1995, SHORT PROTOCOLS MOL

[3]

BRENT GA, 1989, MOL ENDOCRINOL, V6, P1489

[4] Cyclic AMP and fatty acids increase carnitine palmitoyltransferase I gene transcription in cultured fetal rat hepatocytes [J].

Chatelain, F ;

Kohl, C ;

Esser, V ;

McGarry, JD ;

Girard, J ;

Pegorier, JP .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 235 (03) :789-798

[5] A TRANSCRIPTIONAL CO-REPRESSOR THAT INTERACTS WITH NUCLEAR HORMONE RECEPTORS [J].

CHEN, JD ;

EVANS, RM .

NATURE, 1995, 377 (6548) :454-457

[6] Tissue-specific regulation of medium-chain acyl-CoA dehydrogenase gene by thyroid hormones in the developing rat [J].

Djouadi, F ;

Riveau, B ;

MerletBenichou, C ;

Bastin, J .

BIOCHEMICAL JOURNAL, 1997, 324 :289-294

[7]

ESSER V, 1993, J BIOL CHEM, V268, P5817

[8] Leptin, nutrition, and the thyroid: the why, the wherefore, and the wiring [J].

Flier, JS ;

Harris, M ;

Hollenberg, AN .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (07) :859-861

[9] HALF-SITE SPACING AND ORIENTATION DETERMINES WHETHER THYROID-HORMONE AND RETINOIC ACID RECEPTORS AND RELATED FACTORS BIND TO DNA RESPONSE ELEMENTS AS MONOMERS, HOMODIMERS, OR HETERODIMERS [J].

FORMAN, BM ;

CASANOVA, J ;

RAAKA, BM ;

GHYSDAEL, J ;

SAMUELS, HH .

MOLECULAR ENDOCRINOLOGY, 1992, 6 (03) :429-442

[10] A STUDY OF PROPERTIES AND ABUNDANCE OF THE COMPONENTS OF LIVER CARNITINE PALMITOYLTRANSFERASES IN MITOCHONDRIAL INNER AND OUTER MEMBRANES - EFFECTS OF HYPOTHYROIDISM, FASTING AND A KETOTIC DIABETIC STATE [J].

GHADIMINEJAD, I ;

SAGGERSON, ED .

BIOCHEMICAL JOURNAL, 1991, 277 :611-617

← 1 2 3 4 →