Surgical treatment and outcomes in carcinoma of the extrahepatic bile ducts -: The University of Rochester experience

被引:40
作者
Blom, D
Schwartz, SI
机构
[1] Univ Rochester, Sch Med & Dent, Dept Surg, Rochester, NY 14642 USA
[2] Univ So Calif, Dept Surg, Los Angeles, CA 90089 USA
关键词
D O I
10.1001/archsurg.136.2.209
中图分类号
R61 [外科手术学];
学科分类号
摘要
Hypothesis: To our knowledge, few individual surgeons and only a handful of institutions have gained a meaningful experience with the treatment of adenocarcinoma of the extrahepatic bile ducts or cholangiocarcinoma. The purpose of this study was to critically evaluate the experience of a single center in the treatment of these tumors. Design: Retrospective cohort study with a median follow-up of 48 months. Setting: Department of surgery at a university referral center. Patients: Seventy-seven patients with biopsyconfirmed adenocarcinoma of the extrahepatic bile ducts evaluated and treated between January 1980 and February 1998. Main Outcome Measures: Prognostic variables, resectability rates, morbidity, and survival. Results: Thirty-eight male and 39 female patients were studied (median age, 71 years). Twenty-three patients (30%) underwent curative resections, 32 patients (41%) underwent palliative surgery, and 22 patients (29%) received nonoperative therapies. The 30-day perioperative morbidity rate was 18%, and mortality was 6%. Overall median survival was II months; 4 months for patients receiving nonoperative therapy; 8 months for patients recieving palliative surgery; and 72 months for curative resection. Five-year survival rates were 23%, 0% 10%, and 55%, respectively. Curative resection was the only prognostic variable to have a statistically significant effect on survival. Conclusions: Curative resection could be achieved in approximately one third of patients who had cholangiocarcinoma, and should be the goal of treatment. Survival is significantly improved in those patients who are considered to have resectable tumors and who undergo removal of all gross disease. Palliative surgical treatments also revealed a survival advantage over nonoperative therapies.
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页码:209 / 214
页数:6
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