Enhanced in vivo Magnetic Resonance Imaging of Tumors by PEGylated Iron-Oxide-Gold Core-Shell Nanoparticles with Prolonged Blood Circulation Properties

被引：81

作者：

Kumagai, Michiaki ^{[1
]}

Sarma, Tridib Kumar ^{[2
]}

Cabral, Horacio ^{[1
]}

Kaida, Sachiko ^{[1
]}

Sekino, Masaki ^{[3
]}

Herlambang, Nicholas ^{[4
]}

Osada, Kensuke ^{[2
]}

Kano, Mitsunobu R. ^{[5
]}

Nishiyama, Nobuhiro ^{[1
]}

Kataoka, Kazunori ^{[1
,2
]}

机构：

[1] Univ Tokyo, Div Clin Biotechnol, Ctr Dis Biol & Integrat Med, Grad Sch Med, Tokyo 1130033, Japan

[2] Univ Tokyo, Dept Mat Engn, Grad Sch Engn, Bunkyo Ku, Tokyo 1138656, Japan

[3] Univ Tokyo, Dept Adv Energy, Grad Sch Frontier Sci, Chiba 2778561, Japan

[4] Univ Tokyo, Dept Mechanoinformat, Grad Sch Informat Sci & Technol, Bunkyo Ku, Tokyo 1138656, Japan

[5] Univ Tokyo, Grad Sch Med, Dept Mol Pathol, Bunkyo Ku, Tokyo 1130033, Japan

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2010年 / 31卷 / 17期

基金：

日本学术振兴会;

关键词：

gold coatings; iron oxide; magnetic resonance imaging; nanoparticles; poly(ethylene glycol); RAY COMPUTED-TOMOGRAPHY; CONTRAST AGENTS; BLOCK-COPOLYMER; DESIGN; ACCUMULATION; MICELLES; LAYER;

D O I：

10.1002/marc.201000341

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

High-density poly(ethylene glycol) (PEG)-coated iron-oxide-gold core-shell nanoparticles (AuIONs) were developed as T-2-weighted magnetic resonance imaging (MRI) contrast agents for cancer imaging. The PEG-coated iron-oxide-gold core-shell nanoparticles (PEG-AuIONs) were approximately 25 nm in diameter with a narrow distribution. Biodistribution experiments in mice bearing a subcutaneous colon cancer model prepared with C26 murine colon adenocarcinoma cells showed high accumulation of the PEG-AuIONs within the tumor mass and low nonspecific accumulation in the liver and spleen, resulting in high specificity to solid tumors. T-2-weighted MR images following intravenous injection of PEG-AuIONs showed selective negative enhancement of tumor tissue in an orthotopic pancreatic cancer model prepared with Mia-PaCa-2 human pancreatic adenocarcinoma cells. These results indicate that PEG-AuIONs are a promising MRI contrast agent for diagnosis of malignant tumors, including pancreatic cancer.

引用

页码：1521 / 1528

页数：8

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