Cloning of a novel membrane-linked metalloproteinase from human myeloma cells

被引：20

作者：

McKie, N ^{[1
]}

Dallas, DJ ^{[1
]}

Edwards, T ^{[1
]}

Apperley, JF ^{[1
]}

Russell, RGG ^{[1
]}

Croucher, PI ^{[1
]}

机构：

[1] ROYAL POSTGRAD MED SCH,DEPT HAEMATOL,LONDON W12 0NN,ENGLAND

来源：

BIOCHEMICAL JOURNAL | 1996年 / 318卷

关键词：

D O I：

10.1042/bj3180459

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have isolated a novel cDNA from human myeloma cells encoding a member of the reprolysin family of metalloproteinases. Derived amino acid sequence predicts a protein of approx. 76 kDa. The open reading frame predicts the presence of a leader peptide, a pro-peptide with a 'cysteine switch', a metalloproteinase domain, a disintegrin-like domain, a cysteine-rich domain, an epidermal growth factor-like domain and a putative transmembrane sequence. Expression of the mRNA for this metalloproteinase has been demonstrated in human myeloma cells.

引用

页码：459 / 462

页数：4

共 17 条

[1]

BJARNASON JB, 1995, PROTEOLYTIC ENZYMES, P345

[2] PROTEOLYTIC PROCESSING OF A PROTEIN INVOLVED IN SPERM EGG FUSION CORRELATES WITH ACQUISITION OF FERTILIZATION COMPETENCE [J].

BLOBEL, CP ;

MYLES, DG ;

PRIMAKOFF, P ;

WHITE, JM .

JOURNAL OF CELL BIOLOGY, 1990, 111 (01) :69-78

[3] A POTENTIAL FUSION PEPTIDE AND AN INTEGRIN LIGAND DOMAIN IN A PROTEIN ACTIVE IN SPERM-EGG FUSION [J].

BLOBEL, CP ;

WOLFSBERG, TG ;

TURCK, CW ;

MYLES, DG ;

PRIMAKOFF, P ;

WHITE, JM .

NATURE, 1992, 356 (6366) :248-252

[4]

CAWSTON TE, 1995, MECH MODELS RHEUMATO, P333

[5] SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION [J].

CHOMCZYNSKI, P ;

SACCHI, N .

ANALYTICAL BIOCHEMISTRY, 1987, 162 (01) :156-159

[6] THE MATRIX METALLOPROTEINASES AND THEIR NATURAL INHIBITORS - PROSPECTS FOR TREATING DEGENERATIVE TISSUE-DISEASES [J].

DOCHERTY, AJP ;

OCONNELL, J ;

CRABBE, T ;

ANGAL, S ;

MURPHY, G .

TRENDS IN BIOTECHNOLOGY, 1992, 10 (06) :200-207

[7] A NOVEL METALLOPROTEASE DISINTEGRIN-LIKE GENE AT 17Q21.3 IS SOMATICALLY REARRANGED IN 2 PRIMARY BREAST CANCERS [J].

EMI, M ;

KATAGIRI, T ;

HARADA, Y ;

SAITO, H ;

INAZAWA, J ;

ITO, I ;

KASUMI, F ;

NAKAMURA, Y .

NATURE GENETICS, 1993, 5 (02) :151-157

[8]

FOX JW, 1995, PROTEOLYTIC ENZYMES, P368

[9] CHARACTERIZATION OF BONE-MARROW STROMAL CELLS FROM MULTIPLE-MYELOMA [J].

GREGORETTI, MG ;

GOTTARDI, D ;

GHIA, P ;

BERGUI, L ;

MERICO, F ;

MARCHISIO, PC ;

CALIGARISCAPPIO, F .

LEUKEMIA RESEARCH, 1994, 18 (09) :675-682

[10]

MANABE A, 1992, BLOOD, V79, P2370

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