Role of plasmacytoid dendritic cells in immunity and tolerance after allogeneic hematopoietic stem cell transplantation

被引：55

作者：

Arpinati, M

Chirumbolo, G

Urbini, B

Perrone, G

Rondelli, D

Anasetti, C

机构：

[1] Univ Bologna, Ist Ematol & Oncol Med Seragnoli, Ctr Ric Immunol Trapianti, I-40138 Bologna, Italy

[2] Univ Illinois, Hematol Oncol Sect, Chicago, IL USA

[3] Univ Washington, Div Oncol, Dept Med, Fred Hutchinson Canc Res Ctr,Div Clin Res, Seattle, WA USA

来源：

TRANSPLANT IMMUNOLOGY | 2003年 / 11卷 / 3-4期

关键词：

hematopoietic stem cell transplantation; plasmacytoid dendritic cells; myeloid dendritic cells;

D O I：

10.1016/S0966-3274(03)00055-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DC) may play an important role in the pathogenesis of alloimmune reactions, such as graft-vs.-host disease after allogeneic hematopoietic stem cell transplantation (HSCT). In humans, two types of DC-myeloid DC (mDC) and plasmacytoid DC (pDC) have been characterized and have distinct origins and functions. The data obtained from studies in vitro suggest that pDC are involved in the regulation of immunity, including the induction and maintenance of tolerance, as well as in the defence against viruses. The authors will review all the evidence currently available from reports exploring the role of pDC in clinical allogeneic HSCT. (C) 2003 Elsevier B.V. All rights reserved.

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页码：345 / 356

页数：12

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