YbIII-HPDO3A: A Dual pH- and Temperature-Responsive CEST Agent

被引：85

作者：

Delli Castelli, Daniela ^{[1
]}

Terreno, Enzo ^{[1
]}

Aime, Silvio ^{[1
]}

机构：

[1] Univ Turin, Dipartimento Chim IFM, Via Nizza 52, Turin, Italy

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 08期

关键词：

CEST agents; imaging agents; lanthanides; magnetic resonance imaging; SATURATION-TRANSFER AGENTS; CONTRAST AGENTS; MRI APPLICATIONS; COMPLEXES;

D O I：

10.1002/anie.201007105

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A multiple response: YbIII-HPDO3A has been used for the development of a magnetic resonance imaging method that is able to assess pH value and temperature simultaneously, irrespective of the concentration of the complex (see graph). This contrast agent has potential in a clinical setting as it shows the same stability and invivo pharmacokinetic properties as Gd III-HPDO3A, which is already used in clinical practices under the trade name of ProHance. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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页码：1798 / 1800

页数：3

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