A PARACEST Agent Responsive to Inner- And Outer-Sphere Phosphate Ester Interactions for MRI Applications

被引：45

作者：

Huang, Ching-Hui ^{[1
]}

Morrow, Janet R. ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Chem, Amherst, NY 14260 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 12期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

CONTRAST AGENTS; CEST AGENT; EUROPIUM(III); COMPLEXES; CLEAVAGE; GLUCOSE; IONS; RNA;

D O I：

10.1021/ja900290z

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Eu(S-THP)(3+) is the first PARACEST agent that functions through exchange of hydroxyl protons with water protons in aqueous solution. The CEST spectrum of this complex is strongly pH dependent and modulated by the presence of phosphate esters, as shown for diethyl phosphate and methyl phosphate, which form outer- and inner-sphere complexes, respectively, with Eu(S-THP)(3+). The sensitivity of the alcohol proton environment to interactions with these anions shows that this complex has potential as a responsive PARACEST MRI contrast agent.

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页码：4206 / +

页数：3

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