Asymmetric epoxidation of α,β-unsaturated ketones under phase-transfer catalyzed conditions

被引：126

作者：

Arai, S ^{[1
]}

Tsuge, H ^{[1
]}

Shioiri, T ^{[1
]}

机构：

[1] Nagoya City Univ, Fac Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 41期

关键词：

asymmetric reactions; catalysts; epoxidation; phase transfer;

D O I：

10.1016/S0040-4039(98)01646-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric epoxidation of a,b-unsaturated ketones with H2O2 was developed using a chiral quaternary ammonium salt as the phase-transfer catalyst. A catalytic amount of N-[4-(iodo)benzyl]cinchoninium bromide, easily prepared from cinchonine, was effective in the asymmetric epoxidation for producing the corresponding desired products with up to 92% ee under mild reaction conditions. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7563 / 7566

页数：4

共 25 条

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