The immune modulating activity of the Helicobacter pylori HP-NAP: Friend or foe?

被引：48

作者：

de Bernard, Marina ^{[1
,2
]}

D'Elios, Mario M. ^{[3
]}

机构：

[1] Univ Padua, Dept Biol, I-35121 Padua, Italy

[2] Venetian Inst Mol Med, I-35121 Padua, Italy

[3] Univ Florence, Dept Internal Med, I-50134 Florence, Italy

来源：

TOXICON | 2010年 / 56卷 / 07期

关键词：

Helicobacter pylori; HP-NAP; Inflammation; Immune modulation; Th1-Th2; Immunotherapy; NEUTROPHIL-ACTIVATING PROTEIN; HUMAN GASTRIC-MUCOSA; ESCHERICHIA-COLI DPS; RESPIRATORY BURST; OXIDATIVE STRESS; PEPTIC-ULCER; CELLS; INFLAMMATION; CYTOKINE; DNA;

D O I：

10.1016/j.toxicon.2009.09.020

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The Helicobacter pylon HP-NAP is a dodecameric protein with a three-dimensional structure similar to that of bacterioferritins. Originally defined as neutrophil-activating protein, because of its ability to stimulate neutrophils to produce oxygen radicals, HP-NAP is now considered a crucial factor in driving the Th1 inflammation in H. pylori infection. This review summarizes recent studies that have provided a deeper understanding of the pro-inflammatory and immune modulatory properties of HP-NAP. We first examine the role of this protein in the H. pylori-associated disease, and then we discuss recent findings that support the possibility for HP-NAP to become a new tool for therapeutic strategies aimed at redirecting Th2 into Th1 responses, for example in atopy, vaccinology and cancer immunotherapy. (C) 2009 Elsevier Ltd. All rights reserved.

引用

收藏

页码：1186 / 1192

页数：7

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