Immunosenescence: deficits in adaptive immunity in the elderly

被引：154

作者：

Hakim, F. T. ^{[1
]}

Gress, R. E. ^{[1
]}

机构：

[1] NCI, NIH, Expt Transplantat & Immunol Branch, Bethesda, MD 20892 USA

来源：

TISSUE ANTIGENS | 2007年 / 70卷 / 03期

关键词：

aging; cytokines; immunosenescence; immunotherapy; thymus; BONE-MARROW-TRANSPLANTATION; STEM-CELL TRANSPLANTATION; KERATINOCYTE GROWTH-FACTOR; RECEPTOR EXCISION CIRCLE; THYMIC EPITHELIAL-CELLS; REGULATORY T-CELLS; AGE-RELATED DEFECTS; B-LYMPHOPOIESIS; LYMPH-NODES; IN-VIVO;

D O I：

10.1111/j.1399-0039.2007.00891.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aging is associated clinically with increases in the frequency and severity of infectious diseases and an increased incidence of cancer, chronic inflammatory disorders and autoimmunity. These age-associated immune dysfunctions are the consequence of declines in both the generation of new naive T and B lymphocytes and the functional competence of memory populations. These alterations collectively are termed immunosenescence.

引用

页码：179 / 189

页数：11

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