Immunosenescence: deficits in adaptive immunity in the elderly

被引：154

作者：

Hakim, F. T. ^{[1
]}

Gress, R. E. ^{[1
]}

机构：

[1] NCI, NIH, Expt Transplantat & Immunol Branch, Bethesda, MD 20892 USA

来源：

TISSUE ANTIGENS | 2007年 / 70卷 / 03期

关键词：

aging; cytokines; immunosenescence; immunotherapy; thymus; BONE-MARROW-TRANSPLANTATION; STEM-CELL TRANSPLANTATION; KERATINOCYTE GROWTH-FACTOR; RECEPTOR EXCISION CIRCLE; THYMIC EPITHELIAL-CELLS; REGULATORY T-CELLS; AGE-RELATED DEFECTS; B-LYMPHOPOIESIS; LYMPH-NODES; IN-VIVO;

D O I：

10.1111/j.1399-0039.2007.00891.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aging is associated clinically with increases in the frequency and severity of infectious diseases and an increased incidence of cancer, chronic inflammatory disorders and autoimmunity. These age-associated immune dysfunctions are the consequence of declines in both the generation of new naive T and B lymphocytes and the functional competence of memory populations. These alterations collectively are termed immunosenescence.

引用

页码：179 / 189

页数：11

共 103 条

[91] Immunosenescence: Role and measurement in influenza vaccine response among the elderly [J].

Targonski, Paul V. ;

Jacobson, Robert M. ;

Poland, Gregory A. .

VACCINE, 2007, 25 (16) :3066-3069

[92] Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches [J].

Thien, M ;

Phan, TG ;

Gardam, S ;

Amesbury, M ;

Basten, A ;

Mackay, F ;

Brink, R .

IMMUNITY, 2004, 20 (06) :785-798

[93] Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activity [J].

Tsaknaridis, L ;

Spencer, L ;

Culbertson, N ;

Hicks, K ;

LaTocha, D ;

Chou, YK ;

Whitham, RH ;

Bakke, A ;

Jones, RE ;

Offner, H ;

Bourdette, DN ;

Vandenbark, AA .

JOURNAL OF NEUROSCIENCE RESEARCH, 2003, 74 (02) :296-308

[94] Strategies to enhance T-cell reconstitution in immunocompromised patients [J].

van den Brink, MRM ;

Alpdogan, Ö ;

Boyd, RL .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (11) :856-867

[95]

van Ewijk W, 2000, DEVELOPMENT, V127, P1583

[96] Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly:: the Swedish NONA immune study [J].

Wikby, A ;

Johansson, B ;

Olsson, J ;

Löfgren, S ;

Nilsson, BO ;

Ferguson, F .

EXPERIMENTAL GERONTOLOGY, 2002, 37 (2-3) :445-453

[97] Effects of castration on the lymphocytes of the thymus, spleen and lymph nodes [J].

Windmill, KF ;

Lee, VWK .

TISSUE & CELL, 1998, 30 (01) :104-111

[98] Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice [J].

Yang, XH ;

Stedra, J ;

Cerny, J .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (03) :959-970

[99] In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells [J].

Yu, Q ;

Erman, B ;

Bhandoola, A ;

Sharrow, SO ;

Singer, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (04) :475-487

[100] Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans:: a contribution to understand the relationship between inflammation and immuno senescence [J].

Zanni, F ;

Vescovini, R ;

Biasini, C ;

Fagnoni, F ;

Zanlari, L ;

Telera, A ;

Di Pede, P ;

Passeri, G ;

Pedrazzoni, M ;

Passeri, M ;

Franceschi, C ;

Sansoni, P .

EXPERIMENTAL GERONTOLOGY, 2003, 38 (09) :981-987

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