An illustrated review of early pancreas development in the mouse

被引:272
作者
Jorgensen, Mette Christine [1 ]
Ahnfelt-Ronne, Jonas [1 ]
Hald, Jacob [1 ]
Madsen, Ole D. [1 ]
Serup, Palle [1 ]
Hecksher-Sorensen, Jacob [1 ]
机构
[1] Hagedorn Res Inst, Dept Dev Biol, DK-2820 Gentofte, Denmark
关键词
D O I
10.1210/er.2007-0016
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Pancreas morphogenesis and cell differentiation are highly conserved among vertebrates during fetal development. The pancreas develops through simple budlike structures on the primitive gut tube to a highly branched organ containing many specialized cell types. This review presents an overview of key molecular components and important signaling sources illustrated by an extensive three-dimensional (3D) imaging of the developing mouse pancreas at single cell resolution. The 3D documentation covers the time window between embryonic days 8.5 and 14.5 in which all the pancreatic cell types become specified and therefore includes gene expression of pancreatic endocrine hormones, exocrine gene products, and essential transcription factors. The 3D perspective provides valuable insight into how a complex organ like the pancreas is formed and a perception of ventral and dorsal pancreatic growth that is otherwise difficult to uncover. We further discuss how this global analysis of the developing pancreas confirms and extends previous studies, and we envisage that this type of analysis can be instrumental for evaluating mutant phenotypes in the future.
引用
收藏
页码:685 / 705
页数:21
相关论文
共 191 条
[41]   Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme [J].
Edsbagge, J ;
Johansson, JK ;
Esni, F ;
Luo, Y ;
Radice, GL ;
Semb, H .
DEVELOPMENT, 2005, 132 (05) :1085-1092
[42]   Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas [J].
Esni, F ;
Ghosh, B ;
Biankin, AV ;
Lin, JW ;
Albert, MA ;
Yu, XB ;
MacDonald, RJ ;
Civin, CI ;
Real, FX ;
Pack, MA ;
Ball, DW ;
Leach, SD .
DEVELOPMENT, 2004, 131 (17) :4213-4224
[43]   Dorsal pancreas agenesis in N-cadherin-deficient mice [J].
Esni, F ;
Johansson, BR ;
Radice, GL ;
Semb, H .
DEVELOPMENTAL BIOLOGY, 2001, 238 (01) :202-212
[44]   WHAT IS DEVELOPMENTAL FATE OF NEURAL CREST CELLS WHICH MIGRATE INTO PANCREAS IN AVIAN EMBRYO [J].
FONTAINE, J ;
LELIEVRE, C ;
LEDOUARIN, NM .
GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1977, 33 (03) :394-404
[45]   Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas [J].
Fujikura, J ;
Hosoda, K ;
Iwakura, H ;
Tomita, T ;
Noguchi, M ;
Masuzaki, H ;
Tanigaki, K ;
Yabe, D ;
Honjo, T ;
Nakao, K .
CELL METABOLISM, 2006, 3 (01) :59-65
[46]   Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation [J].
Fujitani, Y ;
Fujitani, S ;
Boyer, DF ;
Gannon, M ;
Kawaguchi, Y ;
Ray, M ;
Shiota, M ;
Stein, RW ;
Magnuson, MA ;
Wright, CVE .
GENES & DEVELOPMENT, 2006, 20 (02) :253-266
[47]   The β-cell specific transcription factor Nkx6.1 inhibits glucagon gene transcription by interfering with Pax6 [J].
Gauthier, Benoit R. ;
Gosmain, Yvan ;
Mamin, Aline ;
Philippe, Jacques .
BIOCHEMICAL JOURNAL, 2007, 403 :593-601
[48]   P57 and Hes 1 coordinate cell cycle exit with self-renewal of pancreatic progenitors [J].
Georgia, Senta ;
Soliz, Rosemary ;
Li, Min ;
Zhang, Pumin ;
Bhushan, Anil .
DEVELOPMENTAL BIOLOGY, 2006, 298 (01) :22-31
[49]   Interactions between Hairy/Enhancer of Split-related proteins and the pancreatic transcription factor Ptf1-p48 modulate function of the PTF1 transcriptional complex [J].
Ghosh, B ;
Leach, SD .
BIOCHEMICAL JOURNAL, 2006, 393 :679-685
[50]  
Gittes GK, 1996, DEVELOPMENT, V122, P439