Alkaloids with human δ-opioid receptor binding affinity from the Australian rainforest tree Peripentadenia mearsii

被引：15

作者：

Katavic, Peter L. ^{[1
]}

Venables, Debra A. ^{[1
]}

Guymer, Gordon P. ^{[2
]}

Forster, Paul I. ^{[2
]}

Carroll, Anthony R. ^{[1
]}

机构：

[1] Griffith Univ, Nat Prod Discovery Eskitis Inst, Brisbane, Qld 4111, Australia

[2] Bribane Botan Gardens, Queensland Herbarium, Toowong, Qld 4006, Australia

来源：

JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 12期

关键词：

D O I：

10.1021/np070516x

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new pyrrolidine alkaloids, peripentonine A-C (2-4), one known pyrrolidine alkaloid, peripentadenine (1), and one novel indolizidine alkaloid, mearsamine (5), were isolated from the leaves of Peripentadenia mearsii and their structures determined by ID and 2D NMR spectroscopy. Peripentonines A (2) and B (3) were isolated as a 1: 1 mixture of inseparable diastereomers. Mearsamine (5) contains a novel tricyclic ring system. Peripentadenine and peripentonines A/B and C showed receptor binding affinity for the human delta-opioid receptor with IC50 values of 11.4, 69.2, and 30.9 mu M, respectively. Mearsamine did not bind to the delta-opioid receptor.

引用

页码：1946 / 1950

页数：5

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