Inhibited and uninhibited infants "grown up": Adult amygdalar response to novelty

被引：355

作者：

Schwartz, CE

Wright, CI

Shin, LM

Kagan, J

Rauch, SL

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Psychiat,Dev Psychopathol Res Grp, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Psychiat,Psychiat Neuroimaging Res Program, Charlestown, MA 02129 USA

[3] MGH, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

[4] MGH, Nucl Magnet Resonance Ctr, Charlestown, MA 02129 USA

[5] Brigham & Womens Hosp, Dept Neurol, Brigham Behav Neurol Grp, Boston, MA 02115 USA

[6] Tufts Univ, Dept Psychol, Medford, MA 02155 USA

[7] Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA

来源：

SCIENCE | 2003年 / 300卷 / 5627期

关键词：

D O I：

10.1126/science.1083703

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Infants with an inhibited temperament tend to develop into children who avoid people, objects, and situations that are novel or unfamiliar, whereas uninhibited children spontaneously approach novel persons, objects, and situations. Behavioral and physiological features of these two temperamental categories are moderately stable from infancy into early adolescence and have been hypothesized to be due, in part, to variation in amygdalar responses to novelty. We found that adults who had been categorized in the second year of life as inhibited, compared with those previously categorized as uninhibited, showed greater functional MRI signal response within the amygdala to novel versus familiar faces.

引用

页码：1952 / 1953

页数：2

共 27 条

[1] Further evidence of association between behavioral inhibition and social anxiety in children [J].

Biederman, J ;

Hirshfeld-Becker, DR ;

Rosenbaum, JF ;

Hérot, C ;

Friedman, D ;

Snidman, N ;

Kagan, J ;

Faraone, SV .

AMERICAN JOURNAL OF PSYCHIATRY, 2001, 158 (10) :1673-1679

[2] fMRI reveals amygdala activation to human faces in social phobics [J].

Birbaumer, N ;

Grodd, W ;

Diedrich, O ;

Klose, U ;

Erb, M ;

Lotze, M ;

Schneider, F ;

Weiss, U ;

Flor, H .

NEUROREPORT, 1998, 9 (06) :1223-1226

[3] Behavioral and physiological antecedents of inhibited and uninhibited behavior [J].

Calkins, SD ;

Fox, NA ;

Marshall, TR .

CHILD DEVELOPMENT, 1996, 67 (02) :523-540

[4] IMPLICATIONS OF A LONGITUDINAL-STUDY OF CHILD-DEVELOPMENT FOR CHILD-PSYCHIATRY [J].

CHESS, S ;

THOMAS, A ;

BIRCH, HG ;

HERTZIG, M .

AMERICAN JOURNAL OF PSYCHIATRY, 1960, 117 (05) :434-441

[5]

COLL CG, 1984, CHILD DEV, V55, P1005, DOI 10.1111/j.1467-8624.1984.tb03838.x

[6]

Davidson RJ, 2000, MED RAD DIA IMG, P487

[7] The functional neuroanatomy of emotion and affective style [J].

Davidson, RJ ;

Irwin, W .

TRENDS IN COGNITIVE SCIENCES, 1999, 3 (01) :11-21

[8] STABLE BEHAVIORAL-INHIBITION AND ITS ASSOCIATION WITH ANXIETY DISORDER [J].

HIRSHFELD, DR ;

ROSENBAUM, JF ;

BIEDERMAN, J ;

BOLDUC, EA ;

FARAONE, SV ;

SNIDMAN, N ;

REZNICK, JS ;

KAGAN, J .

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1992, 31 (01) :103-111

[9] THE PHYSIOLOGY AND PSYCHOLOGY OF BEHAVIORAL-INHIBITION IN CHILDREN [J].

KAGAN, J ;

REZNICK, JS ;

SNIDMAN, N .

CHILD DEVELOPMENT, 1987, 58 (06) :1459-1473

[10] Childhood derivatives of high and low reactivity in infancy [J].

Kagan, J ;

Snidman, N ;

Arcus, D .

CHILD DEVELOPMENT, 1998, 69 (06) :1483-1493

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