Imbalance of circulating dendritic cell subsets in chronic obstructive pulmonary disease

被引：43

作者：

Galgani, Mario ^{[2
,3
]}

Fabozzi, Immacolata

Perna, Francesco

Bruzzese, Dario ^{[4
]}

Bellofiore, Barbara

Calabrese, Cecilia ^{[5
]}

Vatrella, Alessandro

Galati, Domenico ^{[6
]}

Matarese, Giuseppe ^{[3
]}

Sanduzzi, Alessandro

Bocchino, Marialuisa ^{[1
]}

机构：

[1] Univ Naples Federico 2, Dept Clin & Expt Med, Resp Med Sect, I-80131 Naples, Italy

[2] Univ Naples Federico 2, Dipartimento Biol & Patol Cellulare & Mol L Calif, I-80131 Naples, Italy

[3] CNR, Ist Endocrinol & Oncol Sperimentale G Salvatore, I-80125 Naples, Italy

[4] Univ Naples Federico 2, Dipartimento Stat Med, I-80131 Naples, Italy

[5] Univ Naples 2, Dipartimento Sci Cardiotorac & Resp, Naples, Italy

[6] Ist Nazl Tumori IRCCS Fdn G Pascale, UOC Immunol, Naples, Italy

来源：

CLINICAL IMMUNOLOGY | 2010年 / 137卷 / 01期

基金：

欧洲研究理事会;

关键词：

COPD; Dendritic cells; Cigarette smoking; HUMAN LUNG; ADAPTIVE IMMUNITY; T-LYMPHOCYTES; HUMAN BLOOD; COPD; SMOKING; ACCUMULATION; INFLAMMATION; SMOKERS; AIRWAYS;

D O I：

10.1016/j.clim.2010.06.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Dendritic cells (DCs) play an unsettled role in chronic obstructive pulmonary disease (COPD) pathogenesis. Two main blood subsets, myeloid (m) and plasmacytoid (p) DCs, have been identified in humans. Phenotype and frequency of circulating DC subsets were assessed by multiparametric flow cytometry in 28 COPD patients and 30 healthy controls (15 never smokers and 15 smokers). Proportion and absolute number of pDCs were significantly reduced in COPD patients in comparison with never smokers (p<0.001 and p<0.003) along with a marked increase of the mDC/pDC ratio (p<0.001). Analysis of peripheral lymphocyte subsets showed that the naive/memory T cell ratio was significantly reduced in COPD patients in comparison with never smokers (p<0.001). Similar perturbations in the distribution of DCs and T cells also occurred in control smokers. This study is the first report of an imbalance of blood DCs in COPD. Influence of smoking and clinical relevance of these findings are discussed. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：102 / 110

页数：9

共 44 条

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Nicotine strongly activates dendritic cell-mediated adaptive immunity - Potential role for progression of atherosclerotic lesions [J].