α,β-unsaturated 2-acyl imidazoles as a practical class of dienophiles for the DNA-Based catalytic asymmetric diels-alder reaction in water

被引：114

作者：

Boersma, Arnold J. ^{[1
]}

Feringa, Ben L. ^{[1
]}

Roelfes, Gerard ^{[1
]}

机构：

[1] Univ Groningen, Stratingh Inst Chem, Dept Organ & Mol Inorgan Chem, NL-9747 AG Groningen, Netherlands

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 18期

关键词：

D O I：

10.1021/ol7015274

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha,beta-Unsaturated 2-acyl imidazoles are a novel and practical class of dienophiles for the DNA-based catalytic asymmetric Diels-Alder reaction in water. The Diels-Alder products are obtained with very high diastereoselectivities and enantioselectivities in the range of 83-98%. The catalytic reaction was performed on a 1.0 mmol scale, and the imidazole auxiliary was removed readily.

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页码：3647 / 3650

页数：4

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