The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

被引：255

作者：

Clark, Richard J. ^{[1
]}

Jensen, Jonas ^{[1
]}

Nevin, Simon T. ^{[2
]}

Callaghan, Brid P. ^{[2
]}

Adams, David J. ^{[2
]}

Craik, David J. ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

[2] Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 37期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

cyclic peptides; drug design; GABA(B) receptor; calcium channels; neuropathic pain; NICOTINIC ACETYLCHOLINE-RECEPTORS; VC1.1; RAT;

D O I：

10.1002/anie.201000620

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

From killers to curers: Peptides from cone snail venoms are potential therapeutic agents for the treatment of neuropathic pain. Unfortunately, these peptides suffer from the disadvantage of short biological half-lives and poor activity when taken orally. A new orally active conotoxin was developed to solve these problems.© 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6545 / 6548

页数：4

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