A new study challenges the current belief of a high human male:female mutation ratio

被引:12
作者
Crow, JF [1 ]
机构
[1] Univ Wisconsin, Dept Genet, Madison, WI 53706 USA
关键词
D O I
10.1016/S0168-9525(00)02136-3
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
A recent comparison of a DNA region that was transposed from the X to the Y chromosome 3-4 million years ago, with the same region on the X chromosome showed only a slight excess of mutant changes on the Y chromosome. This translates to an estimate of 1.7 for the ratio of the male to female mutation rate, much less than the average 5.1 of previous studies. The authors argue that this throws doubt not only an higher male mutation rates in human ancestry, but also on the standard assumption of a high mate:female ratio in contemporary human populations. Clearly, more studies are needed to clear up this discrepancy in the ancestral rates, but I believe that the high contemporary male:female ratio far base substitutions is too well established to be overthrown by even a very good evolutionary study.
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页码:525 / 526
页数:2
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