T cells expressing killer cell inhibitory receptors do not carry TCR for alloantigens

被引：10

作者：

Yamada, N

Nagatani, T

Takiguchi, M

机构：

[1] Kumamoto Univ, Ctr AIDS Res, Div Viral Immunol, Kumamoto 862, Japan

[2] Univ Tokyo, Inst Med Sci, Dept Tumor Biol, Minato Ku, Tokyo 108, Japan

[3] Yokohama City Univ, Sch Med, Dept Dermatol, Kanazawa Ku, Yokohama, Kanagawa 236, Japan

来源：

HUMAN IMMUNOLOGY | 1998年 / 59卷 / 08期

关键词：

D O I：

10.1016/S0198-8859(98)00044-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of T cells carrying the killer cell inhibitory receptor (KIR) is unknown. Here we investigate the allo-response of KIR(+)CD3(+) cells (KIR+ T cells). KIR+ T cells was found in 4.6-14.7% of the T cells from the PBMC of healthy individuals. Flow cytometry analysis showed that the percentage of KIR+ T cells in T cells From three individuals was decreased after stimulation with allogeneic PBMC. These findings suggest that KIR+ T cells do nor respond to alloantigens. Furthermore, the analyses using purified KIR+ T cells also confirmed that KIR+ T cells do not respond to alloantigens. Human Immunology 59, 488-492 (1998). (C) American Society for Histocompatibility and Immunogenetics, 1998. Published by Elsevier Science Inc.

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收藏

页码：488 / 492

页数：5

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