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THE ENIGMA OF THE NATURAL-KILLER-CELL

被引：238
作者：
GUMPERZ, JE [1 ]
PARHAM, P [1 ]
机构：
[1] STANFORD UNIV, DEPT MICROBIOL & IMMUNOL, STANFORD, CA 94305 USA
来源：
NATURE | 1995年 / 378卷 / 6554期
关键词：
D O I：
10.1038/378245a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Natural killer (NK) cells are controlled by receptors specific for polymorphic determinants of class I molecules of the major histocompatibility complex (MHC). The contrasting properties of NK and cytotoxic T cell (CTL) class I receptors provide complementarity in the cytolytic lymphocyte response to viruses, tumours and transplants. Whereas human NK cell class I receptors consist of immunoglobulin domains, their mouse counterparts resemble C-type lectins. This difference may reflect the receptors' diverse and rapidly evolving class I ligands.
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收藏
页码：245 / 248
页数：4
相关论文
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