Chemokine expression in coronary circulation after coronary angioplasty as a prognostic factor for restenosis

被引:31
作者
Hojo, Y [1 ]
Ikeda, U [1 ]
Katsuki, T [1 ]
Mizuno, O [1 ]
Fukazawa, H [1 ]
Fujikawa, H [1 ]
Shimada, K [1 ]
机构
[1] Jichi Med Sch, Dept Cardiol, Minami Kawachi, Tochigi 3290498, Japan
关键词
restenosis; angioplasty; leukocytes;
D O I
10.1016/S0021-9150(00)00611-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Recent studies have clarified the significance of chemokines in cardiovascular diseases. such as development of atherosclerosis, atheromatous plaque rupture and restenosis after coronary angioplasty, We investigated changes in chemokine expression in the coronary circulation induced by percutaneous transluminal coronary angioplasty (PTCA) and their clinical significance. We examined 40 patients with angina pectoris who underwent elective PTCA for isolated stenotic lesions of the left coronary artery. Eight patients received PTCA only. 14 percutaneous transluminal relational atherectomy and 18 stent implantation. Venous blood samples were obtained from the coronary sinus before, and immediately after as well as 4 and 24 h after PTCA. Plasma levels of interleukin (IL)-8, macrophage-colony stimulating factor (M-CSF) and monocyte chemoattractant protein-1 (MCP)-1 were measured by enzyme-linked immunosorbent assay. Plasma levels of M-CSF in the coronary sinus blood showed significant increases 4 and 24 h after PTCA. On the other hand, plasma MCP-I levels did not change significantly during a 24-h observation period after PTCA. Immunoreactive IL-8 was not detected in any patients before or after PTCA. A significant positive correlation was found between plasma M-CSF levels 24 h after PTCA and late loss index 6 months after the procedure. Plasma levels of M-CSF 24 h after PTCA were significantly higher in patients with than in those without late restenosis. PTCA induced increases in plasma levels of M-CSF in the coronary circulation. Increased M-CSF expression may be involved in neointima formation at injured vessels through activation of mononuclear phagocytes. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:165 / 170
页数:6
相关论文
共 31 条
[11]   INDUCTION OF INTERLEUKIN-6 SYNTHESIS IN THE MYOCARDIUM - POTENTIAL ROLE IN POSTREPERFUSION INFLAMMATORY INJURY [J].
KUKIELKA, GL ;
SMITH, CW ;
MANNING, AM ;
YOUKER, KA ;
MICHAEL, LH ;
ENTMAN, ML .
CIRCULATION, 1995, 92 (07) :1866-1875
[12]   INTERLEUKIN-8 GENE INDUCTION IN THE MYOCARDIUM AFTER ISCHEMIA AND REPERFUSION IN-VIVO [J].
KUKIELKA, GL ;
SMITH, CW ;
LAROSA, GJ ;
MANNING, AM ;
MENDOZA, LH ;
DALY, TJ ;
HUGHES, BJ ;
YOUKER, KA ;
HAWKINS, HK ;
MICHAEL, LH ;
ROT, A ;
ENTMAN, ML .
JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (01) :89-103
[13]  
LIBBY P, 1992, CIRCULATION, V86, P47
[14]   Enhanced inflammatory response to coronary angioplasty in patients with severe unstable angina [J].
Liuzzo, G ;
Buffon, A ;
Biasucci, LM ;
Gallimore, JR ;
Caligiuri, G ;
Vitelli, A ;
Altamura, S ;
Ciliberto, G ;
Rebuzzi, AG ;
Crea, F ;
Pepys, MB ;
Maseri, A .
CIRCULATION, 1998, 98 (22) :2370-2376
[15]   Induction of cytokine expression in leukocytes in acute myocardial infarction [J].
Marx, N ;
Neumann, FJ ;
Ott, I ;
Gawaz, M ;
Koch, W ;
Pinkau, T ;
Schomig, A .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1997, 30 (01) :165-170
[16]   Assessment of coagulation and platelet activation in coronary sinus blood induced by transcatheter coronary intervention for narrowing of the left anterior descending coronary artery [J].
Mizuno, O ;
Hojo, Y ;
Ikeda, U ;
Katsuki, TA ;
Fukazawa, H ;
Kurosaki, K ;
Fujikawa, H ;
Shimada, K .
AMERICAN JOURNAL OF CARDIOLOGY, 2000, 85 (02) :154-160
[17]   Macrophage infiltration predicts restenosis after coronary intervention in patients with unstable angina [J].
Moreno, PR ;
Bernardi, VH ;
LopezCuellar, J ;
Newell, JB ;
McMellon, C ;
Gold, HK ;
Palacios, IF ;
Fuster, V ;
Fallon, JT .
CIRCULATION, 1996, 94 (12) :3098-3102
[18]   Adenovirus-mediated gene transfer of macrophage colony stimulating factor to the arterial wall in vivo [J].
Mozes, G ;
Mohacsi, T ;
Gloviczki, P ;
Menawat, S ;
Kullo, I ;
Spector, D ;
Taylor, J ;
Crotty, TB ;
O'Brien, T .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1998, 18 (07) :1157-1163
[19]   Intraperitoneal administration of anti-c-fms monoclonal antibody prevents initial events of atherogenesis but does not reduce the size of advanced lesions in apolipoprotein E-deficient mice [J].
Murayama, T ;
Yokode, M ;
Kataoka, H ;
Imabayashi, T ;
Yoshida, H ;
Sano, H ;
Nishikawa, S ;
Nishikawa, S ;
Kita, T .
CIRCULATION, 1999, 99 (13) :1740-1746
[20]   CARDIAC RELEASE OF CYTOKINES AND INFLAMMATORY RESPONSES IN ACUTE MYOCARDIAL-INFARCTION [J].
NEUMANN, FJ ;
OTT, I ;
GAWAZ, M ;
RICHARDT, G ;
HOLZAPFEL, H ;
JOCHUM, M ;
SCHOMIG, A .
CIRCULATION, 1995, 92 (04) :748-755