The effects of HIV on P300 are moderated by familial risk for substance dependence: Implications for a theory of brain reserve

被引:8
作者
Bauer, Lance O. [1 ]
机构
[1] Univ Connecticut, Sch Med, Dept Psychiat, Farmington, CT 06030 USA
关键词
HIV-1; family history; P300; IQ; event related potentials;
D O I
10.1016/j.drugalcdep.2007.10.012
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Background: The goal of the study was to test the validity of additive versus synergistic versus underadditive versions of brain reserve theory within the context of HIV/AIDS. In addition, it tested the convergent validity of 2 operational definitions of premorbid reserve: verbal IQ (VIQ) and a family history (FH) of substance abuse or dependence. Methods: Seventy HIV-1 seronegative and 115 HIV-1 seropositive male and female volunteers were assigned to 4 subgroups defined by the crossing of a VIQ score < versus >= 90 with the presence versus absence of a paternal history of alcohol, cocaine, or opiate abuse or dependence. The principal dependent measure was the P300 event related brain potential elicited during the Stroop color-word interference task. Results: The principal finding was an underadditive effect of FH plus HIV/AIDS on P300 area over the frontal region: FH reduced frontal scalp P300 to such a degree that the additional effects of HIV/AIDS were blunted. The alternate operational definition of brain reserve, VIQ, had no effect on P300 and did not alter the effects of HIV/AIDS. Conclusions: Familial risk for substance dependence and low VIQ compromise different aspects of brain structure and/or function and therefore differ in their relationship to HIV/AIDS and P300. Genetic differences associated with familial risk may reduce brain reserve to such a degree that the neurophysiological effects of HIV/AIDS can no longer be measured. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:92 / 100
页数:9
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